PDE4A10 blocking peptide

PDE4A10 Peptide

Gene Names

Pde4a; PHOSA

Applications

Immunocompetition, Immunodepletion

Synonyms

PDE4A10; PDE4A10 Peptide; 5''-cyclic phosphodiesterase 4A10; PDE46; phosphodiesterase 4A10 cAMP specific; phosphodiesterase isozyme 4A10; phosphodiesterase type 4A10 antibody; PDE4A10 blocking peptide

Ordering
Cat. Num. AAA544192 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Form/Format

Antigenic Blocking Peptide

Concentration

Quantity: 250 ug; Volume: 100 ul (varies by lot)

Sequence Length

771

Applicable Applications for PDE4A10 blocking peptide

Immunocompetition, Immunodepletion

Application Notes

Western Blot: 1:500

Immunogen

Synthetic peptide taken within amino acid region 1-50 on PDE4A10 protein.

Expression

Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Iso

Determinant

C-epitope

Molecular Function

cAMP

Structure

Belongs to cyclic nucleotide phosphodiesterase family. PDE4 subfamily

Subcellular Location

Isoform 1: perinuclear region, Isoform 2: ruffle membrane, Isoform 4: Peripheral membrane protein, Isoform 6: perinuclear region, Isoform 7: Membrane, Cytoplasm

Preparation and Storage

-20 degree C for long term storage

Related Product Information for PDE4A10 blocking peptide

Antigenic Blocking Peptide Phosphodiesterase 4A10 C-epitope
Hydrolyzes the second messenger cAMP which is a key regulator of many important physiological processes.

NCBI and Uniprot Product Information

NCBI GI #

12057233

NCBI GeneID

25638

UniProt Accession #

P27815; O75522; O76092; Q16255; Q16691; Q5DM53; Q6PMT2; Q8IVA7; Q8WUQ3; Q9H3H2; P54748

Molecular Weight

95,571 Da

NCBI Official Full Name

cyclic AMP phosphodiesterase PDE4A10, partial

NCBI Official Synonym Full Names

phosphodiesterase 4A

NCBI Official Symbol

Pde4a

NCBI Official Synonym Symbols

PHOSA

NCBI Protein Information

cAMP-specific 3',5'-cyclic phosphodiesterase 4A

UniProt Protein Name

cAMP-specific 3',5'-cyclic phosphodiesterase 4A

UniProt Gene Name

PDE4A

UniProt Synonym Gene Names

DPDE2

UniProt Entry Name

PDE4A_HUMAN

NCBI Description

human homolog catalyzes the hydrolysis of cAMP; activity is inhibited by rolipram [RGD, Feb 2006]

Uniprot Description

PDE4A: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Isoform 1 interacts with LYN. Isoform 2 and isoform 6 interact weakly with LYN. Isoform 1, isoform 2 and isoform 6 interact with ARRB2. Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Isoform 6 is expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes. Isoform 7 is expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Isoform 7 is expressed in the brain. Found in specific neuronal subpopulations in cortex, spinal cord and cerebellum. Isoform 1, isoform 2, isoform 6 and isoform 7 are inhibited by rolipram and cilomilast. Isoform 1, isoform 2 and isoform 6 are inhibited by 4-[(3-butoxy-4-methoxyphenyl)-methyl]- 2-imidazolidinone (Ro 20-1724), roflumilast and denbufylline. Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: cytosol; membrane; perinuclear region of cytoplasm

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; cAMP binding; metal ion binding; protein binding

Biological Process: cAMP catabolic process; sensory perception of smell; signal transduction

Research Articles on PDE4A10

1. ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertion.

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Product Notes

The PDE4A10 pde4a (Catalog #AAA544192) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's PDE4A10 can be used in a range of immunoassay formats including, but not limited to, Immunocompetition, Immunodepletion. Western Blot: 1:500. Researchers should empirically determine the suitability of the PDE4A10 pde4a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PDE4A10, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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