PACSIN2 blocking peptide

PACSIN2 Antibody (C-term) Blocking Peptide

• Gene Names: PACSIN2; SDPII
• Synonyms: PACSIN2; PACSIN2 Antibody (C-term) Blocking Peptide; Protein kinase C and casein kinase substrate in neurons protein 2; Syndapin-2; Syndapin-II; PACSIN2 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human PACSIN2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 486

• Cellular Location: Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome Recycling endosome membrane. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Membrane, caveola. Note: Detected at the neck of flask-shaped caveolae. Localization to tubular recycling endosomes probably requires interaction with MICALL1 and EHD1
• Tissue Location: Widely expressed.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PACSIN2 blocking peptide

Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle- mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis.

NCBI and Uniprot Product Information

• NCBI GI #: 22256968
• NCBI GeneID: 11252
• UniProt Accession #: Q9UNF0; O95921; Q96HV9; Q9H0D3; Q9NPN1; Q9Y4V2
• Molecular Weight: 51,353 Da
• NCBI Official Full Name: Protein kinase C and casein kinase substrate in neurons protein 2
• NCBI Official Synonym Full Names: protein kinase C and casein kinase substrate in neurons 2
• NCBI Official Symbol: PACSIN2
• NCBI Official Synonym Symbols: SDPII
• NCBI Protein Information: protein kinase C and casein kinase substrate in neurons protein 2
• UniProt Protein Name: Protein kinase C and casein kinase substrate in neurons protein 2
• Protein Family: Protein kinase C and casein kinase substrate in neurons protein
• UniProt Gene Name: PACSIN2
• UniProt Entry Name: PACN2_HUMAN

NCBI Description

This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation by regulating tubulin polymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Uniprot Description

PACSIN2: May play a role in vesicle formation and transport. Belongs to the PACSIN family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 22q13.2-q13.33

Cellular Component: caveola; cytoplasm; extrinsic to membrane; focal adhesion; intracellular membrane-bound organelle; nucleoplasm; recycling endosome membrane

Molecular Function: identical protein binding; protein binding; transporter activity

Biological Process: cell projection morphogenesis; regulation of endocytosis