P2RX2 blocking peptide

P2RX2 Antibody (N-term) Blocking Peptide

• Gene Names: P2RX2; P2X2; DFNA41
• Synonyms: P2RX2; P2RX2 Antibody (N-term) Blocking Peptide; P2X purinoceptor 2; P2X2; ATP receptor; Purinergic receptor; P2RX2 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 471

• Cellular Location: Cell membrane; Multi-pass membrane protein Note: Localizes to the apical membranes of hair cells in the organ of Corti
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for P2RX2 blocking peptide

Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle.

NCBI and Uniprot Product Information

• NCBI GI #: 12643353
• NCBI GeneID: 22953
• UniProt Accession #: Q9UBL9; Q6V9R6; Q9NR37; Q9NR38; Q9UHD5; Q9UHD6; Q9UHD7; A6NGB4; A6NH93; A6NHC2; A6NHU3; A6NIG9
• Molecular Weight: 41,370 Da
• NCBI Official Full Name: P2X purinoceptor 2
• NCBI Official Synonym Full Names: purinergic receptor P2X 2
• NCBI Official Symbol: P2RX2
• NCBI Official Synonym Symbols: P2X2; DFNA41
• NCBI Protein Information: P2X purinoceptor 2
• UniProt Protein Name: P2X purinoceptor 2
• Protein Family: P2X purinoceptor
• UniProt Gene Name: P2RX2
• UniProt Synonym Gene Names: P2X2; P2X2
• UniProt Entry Name: P2RX2_HUMAN

NCBI Description

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2013]

Uniprot Description

P2X2: Binding of this ligand-gated ion channel to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Belongs to the P2X receptor family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral; Channel, cation

Chromosomal Location of Human Ortholog: 12q24.33

Cellular Component: apical plasma membrane; integral to nuclear inner membrane; integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: ATP-gated cation channel activity; identical protein binding; ligand-gated ion channel activity; purinergic nucleotide receptor activity

Biological Process: blood coagulation; protein homooligomerization; sensory perception of sound

Disease: Deafness, Autosomal Dominant 41