Western Blot (WB)
(Western blot analysis of NKX2-6 in mouse spleen tissue lysate with NKX2-6 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.)
NKX2-6 blocking peptide
NKX2-6 Peptide
Western Blot (WB)
(Western blot analysis of NKX2-6 in mouse spleen tissue lysate with NKX2-6 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.)
Western Blot (WB)
(Western blot analysis of NKX2-6 in mouse spleen tissue lysate with NKX2-6 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a homeobox-containing protein that belongs to the NK-2 homeobox family. This protein is a vertebrate homolog of Drosophila homeobox-containing protein called 'tinman', which has been shown to be essential for development of the heart-like dorsal vessel. In conjunction with related gene, NKX2-5, this gene may play a role in both pharyngeal and cardiac embryonic development. Mutations in this gene are associated with persistent truncus arteriosus.[provided by RefSeq, Aug 2011]
Uniprot Description
NKX2-6: In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development. Defects in NKX2-6 may be a cause of conotruncal heart malformations (CTHM). CTHM defines a group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle. Belongs to the NK-2 homeobox family.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 8p21.2
Cellular Component: nucleus
Molecular Function: sequence-specific DNA binding; transcription factor activity
Biological Process: tongue development; pericardium development; hypothalamus development; pharyngeal system development; atrial cardiac muscle cell development; gut development; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ventricular cardiac muscle cell development; positive regulation of cell proliferation; embryonic heart tube development; cell differentiation; negative regulation of apoptosis
Disease: Conotruncal Heart Malformations
Research Articles on NKX2-6
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Product Notes
The NKX2-6 nkx2-6 (Catalog #AAA153289) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's NKX2-6 can be used in a range of immunoassay formats including, but not limited to, Blocking (BL). NKX2-6 peptide is used for blocking the activity of NKX2-6 antibody. Researchers should empirically determine the suitability of the NKX2-6 nkx2-6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NKX2-6, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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