NFKBIL1 blocking peptide

NFKBIL1 Blocking Peptide

Cat. Num. AAA9628087

• Gene Names: NFKBIL1; IKBL; LST1; NFKBIL
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: NFKBIL1; NFKBIL1 Blocking Peptide; I-kappa-B-like protein; IkappaBL; IKBL; IKBL1_HUMAN; Inhibitor of kappa B-like protein; LST1; NF-kappa-B inhibitor-like protein 1; NFKBIL; Nfkbil1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1; NFKBIL1 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for NFKBIL1 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for NFKBIL1 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 222352175
• NCBI GeneID: 4795
• NCBI Accession #: NP_001138433.1
• NCBI GenBank Nucleotide #: NM_001144961.1
• UniProt Accession #: Q9UBC1; Q14625; Q5HYU4; Q5RJ72; Q5ST96; Q5STV4; Q5STV5; Q9UBX4; A6NL91; B4DUW1
• Molecular Weight: 41,368 Da
• NCBI Official Full Name: NF-kappa-B inhibitor-like protein 1 isoform 2
• NCBI Official Synonym Full Names: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
• NCBI Official Symbol: NFKBIL1
• NCBI Official Synonym Symbols: IKBL; LST1; NFKBIL
• NCBI Protein Information: NF-kappa-B inhibitor-like protein 1
• UniProt Protein Name: NF-kappa-B inhibitor-like protein 1
• Protein Family: NF-kappa-B inhibitor-like protein
• UniProt Gene Name: NFKBIL1
• UniProt Synonym Gene Names: IKBL; I-kappa-B-like protein; IkappaBL

NCBI Description

This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

Uniprot Description

NFKBIL1: Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon- regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. Defects in NFKBIL1 are a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription regulation

Chromosomal Location of Human Ortholog: 6p21.33

Cellular Component: intermediate filament cytoskeleton; nucleoplasm; nucleus

Molecular Function: protein binding

Biological Process: cytoplasmic sequestering of transcription factor; I-kappaB kinase/NF-kappaB cascade; inhibition of NF-kappaB transcription factor; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of toll-like receptor signaling pathway; negative regulation of tumor necrosis factor production

Disease: Rheumatoid Arthritis