NELL1 blocking peptide

NELL1 Blocking Peptide (C-term)

Gene Names

NELL1; NRP1; IDH3GL

Synonyms

NELL1; NELL1 Blocking Peptide (C-term); Protein kinase C-binding protein NELL1; NEL-like protein 1; Nel-related protein 1; NRP1; NELL1 blocking peptide

Ordering

Specificity

The synthetic peptide sequence is selected from aa 696-708 of HUMAN NELL1

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Sequence Length

810

Cellular Location

Cytoplasm. Nucleus envelope. Secreted. Note: Colocalizes with ATRAID on the nuclear envelope and the perinuclear region

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for NELL1 blocking peptide

Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization.

NCBI and Uniprot Product Information

NCBI GI #

311033486

NCBI GeneID

4745

UniProt Accession #

Q92832; Q4VB90; Q4VB91; Q6NSY8; Q9Y472; B2CKC1

Molecular Weight

84,377 Da

NCBI Official Full Name

Protein kinase C-binding protein NELL1

NCBI Official Synonym Full Names

neural EGFL like 1

NCBI Official Symbol

NELL1

NCBI Official Synonym Symbols

NRP1; IDH3GL

NCBI Protein Information

protein kinase C-binding protein NELL1

UniProt Protein Name

Protein kinase C-binding protein NELL1

Protein Family

Protein kinase C-binding protein

UniProt Gene Name

NELL1

UniProt Synonym Gene Names

NRP1

UniProt Entry Name

NELL1_HUMAN

NCBI Description

This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Uniprot Description

NELL1: Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: cytoplasm; nuclear envelope; perinuclear region of cytoplasm

Molecular Function: protein binding

Biological Process: negative regulation of osteoblast proliferation; nervous system development; positive regulation of bone mineralization; positive regulation of osteoblast differentiation; regulation of gene expression

Research Articles on NELL1

1. establish the feasibility of combining NELL-1 with BMP2 to improve clinical bone regeneration and provide mechanistic insight into canonical Wnt pathway activity during NELL-1 and BMP2 osteogenesis

Similar Products

Product Notes

The NELL1 nell1 (Catalog #AAA9230121) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "NELL1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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NELL1 blocking peptide