NDST3 blocking peptide

NDST3 Antibody (C-term) Blocking Peptide

• Gene Names: NDST3; HSST3
• Synonyms: NDST3; NDST3 Antibody (C-term) Blocking Peptide; Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3; Glucosaminyl N-deacetylase/N-sulfotransferase 3; NDST-3; hNDST-3; N-heparan sulfate sulfotransferase 3; N-HSST 3; Heparan sulfate N-deacetylase 3; 3---; Heparan sulfate N-sulfotransferase 3; 282-; HSST3; NDST3 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 873

• Cellular Location: Golgi apparatus membrane; Single-pass type II membrane protein
• Tissue Location: Expressed in brain, kidney, liver, fetal and adult lung, adult pancreas, placenta, fetal spleen and fetal thymus. Not detected in adult/ fetal heart and skeletal muscle
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for NDST3 blocking peptide

Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity.

NCBI and Uniprot Product Information

• NCBI GI #: 74706081
• NCBI GeneID: 9348
• UniProt Accession #: O95803; Q4W5C1; Q4W5D0; Q6UWC5; Q9UP21; B4DI67
• Molecular Weight: 64,297 Da
• NCBI Official Full Name: Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3
• NCBI Official Synonym Full Names: N-deacetylase and N-sulfotransferase 3
• NCBI Official Symbol: NDST3
• NCBI Official Synonym Symbols: HSST3
• NCBI Protein Information: bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3
• UniProt Protein Name: Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3
• Protein Family: Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase
• UniProt Gene Name: NDST3
• UniProt Synonym Gene Names: HSST3; NDST-3; hNDST-3; N-HSST 3
• UniProt Entry Name: NDST3_HUMAN

NCBI Description

This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. This monomeric bifunctional enzyme catalyzes the N-deacetylation and N-sulfation of N-acetylglucosamine residues in heparan sulfate and heparin, which are the initial chemical modifications required for the biosynthesis of the functional oligosaccharide sequences that define the specific ligand binding activities of heparan sulfate and heparin. [provided by RefSeq, Nov 2008]

Uniprot Description

NDST3: Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity. Belongs to the sulfotransferase 1 family. NDST subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Glycan Metabolism - heparan sulfate biosynthesis; Membrane protein, integral; Transferase; EC 2.8.2.8; Hydrolase

Chromosomal Location of Human Ortholog: 4q26