NDC80 blocking peptide

NDC80 Blocking Peptide (C-Term)

Gene Names

NDC80; HEC; HEC1; TID3; KNTC2; HsHec1; hsNDC80

Synonyms

NDC80; NDC80 Blocking Peptide (C-Term); Kinetochore protein NDC80 homolog; Highly expressed in cancer protein; Kinetochore protein Hec1; HsHec1; Kinetochore-associated protein 2; Retinoblastoma-associated protein HEC; HEC; HEC1; KNTC2; NDC80 blocking peptide

Ordering

Specificity

The synthetic peptide sequence is selected from aa 528-539 of HUMAN NDC80

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Sequence Length

642

Cellular Location

Nucleus. Chromosome, centromere, kinetochore. Note: Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for NDC80 blocking peptide

Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.

NCBI and Uniprot Product Information

NCBI GI #

74735330

NCBI GeneID

10403

UniProt Accession #

O14777; Q6PJX2

Molecular Weight

73,913 Da

NCBI Official Full Name

Kinetochore protein NDC80 homolog

NCBI Official Synonym Full Names

NDC80, kinetochore complex component

NCBI Official Symbol

NDC80

NCBI Official Synonym Symbols

HEC; HEC1; TID3; KNTC2; HsHec1; hsNDC80

NCBI Protein Information

kinetochore protein NDC80 homolog

UniProt Protein Name

Kinetochore protein NDC80 homolog

Protein Family

Kinetochore protein

UniProt Gene Name

NDC80

UniProt Synonym Gene Names

HEC; HEC1; KNTC2; HsHec1

UniProt Entry Name

NDC80_HUMAN

NCBI Description

This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011]

Uniprot Description

HEC1: plays an essential role in chromosome segregation by interacting through its coiled-coil domains with several proteins that modulate the G2/M phase. Phosphorylation by Nek2 is essential for faithful chromosome segregation. Required for the recruitment of Mps1 kinase and Mad1/Mad2 complexes to kinetochores.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 18p11.32

Cellular Component: chromosome, pericentric region; cytosol; kinetochore; membrane; nucleus

Molecular Function: identical protein binding; protein binding; structural constituent of cytoskeleton

Biological Process: attachment of spindle microtubules to kinetochore; attachment of spindle microtubules to kinetochore during mitosis; chromosome segregation; establishment of mitotic spindle orientation; mitosis; mitotic sister chromatid segregation; mitotic spindle organization and biogenesis; sister chromatid cohesion

Research Articles on NDC80

1. Independent molecular binding events to microtubules (MTs) by individual NDC80 complexes, rather than their structured oligomers, regulate the dynamics and stability of kinetochore-MT attachments in dividing cells.

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Product Notes

The NDC80 ndc80 (Catalog #AAA9230658) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "NDC80, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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NDC80 blocking peptide