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NCKAP1 blocking peptide

NCKAP1 Antibody (Center) Blocking peptide

Gene Names
NCKAP1; HEM2; NAP1; NAP125; p125Nap1
Synonyms
NCKAP1; NCKAP1 Antibody (Center) Blocking peptide; Nck-associated protein 1; NAP 1; Membrane-associated protein HEM-2; p125Nap1; HEM2; KIAA0587; NAP1; NCKAP1 blocking peptide
Ordering
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
1128
Cellular Location
Cell membrane; Single-pass membrane protein; Cytoplasmic side Cell projection, lamellipodium membrane; Single-pass membrane protein; Cytoplasmic side Note: At the interface between the lamellipodial actin meshwork and the membrane.
Tissue Location
Expressed in all tissues examined except peripheral blood leukocytes, with highest expression in brain, heart, and skeletal muscle
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for NCKAP1 blocking peptide
Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
129,517 Da
NCBI Official Full Name
nck-associated protein 1 isoform 1
NCBI Official Synonym Full Names
NCK associated protein 1
NCBI Official Symbol
NCKAP1
NCBI Official Synonym Symbols
HEM2; NAP1; NAP125; p125Nap1
NCBI Protein Information
nck-associated protein 1
UniProt Protein Name
Nck-associated protein 1
Protein Family
UniProt Gene Name
NCKAP1
UniProt Synonym Gene Names
HEM2; KIAA0587; NAP1; NAP 1
UniProt Entry Name
NCKP1_HUMAN

Uniprot Description

NCKAP1: Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Belongs to the HEM-1/HEM-2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q32

Cellular Component: cytosol; focal adhesion

Molecular Function: protein binding; protein complex binding; Rac GTPase binding

Biological Process: apoptosis; central nervous system development; Rac protein signal transduction; vascular endothelial growth factor receptor signaling pathway

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Product Notes

The NCKAP1 nckap1 (Catalog #AAA9225849) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "NCKAP1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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