MX1 blocking peptide

MX1 Antibody (Center) Blocking Peptide

• Gene Names: MX1; MX; MxA; IFI78; IFI-78K
• Synonyms: MX1; MX1 Antibody (Center) Blocking Peptide; Interferon-induced GTP-binding protein Mx1; Interferon-induced protein p78; IFI-78K; Interferon-regulated resistance GTP-binding protein MxA; Myxoma resistance protein 1; Myxovirus resistance protein 1; N-terminally processed; MX1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 662

• Cellular Location: Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region. Note: Binds preferentially to negatively charged phospholipids. Colocalizes with CCHFV protein N in the perinuclear region
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MX1 blocking peptide

Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.

NCBI and Uniprot Product Information

• NCBI GI #: 251757499
• NCBI GeneID: 4599
• UniProt Accession #: P20591; Q86YP5; Q96CI3; B2RDA5; B3KU10; C9IYV7; C9J8D6; C9JN19; C9JN88; C9JUL1; C9JZS6; D3DSI8
• Molecular Weight: 55,661 Da
• NCBI Official Full Name: Interferon-induced GTP-binding protein Mx1
• NCBI Official Synonym Full Names: MX dynamin like GTPase 1
• NCBI Official Symbol: MX1
• NCBI Official Synonym Symbols: MX; MxA; IFI78; IFI-78K
• NCBI Protein Information: interferon-induced GTP-binding protein Mx1
• UniProt Protein Name: Interferon-induced GTP-binding protein Mx1
• Protein Family: Interferon-induced GTP-binding protein
• UniProt Gene Name: MX1
• UniProt Synonym Gene Names: IFI-78K
• UniProt Entry Name: MX1_HUMAN

NCBI Description

This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Uniprot Description

MX1: Dynamin-like GTPase acting as a cell-autonomous host restriction factor against many viral pathogens. Shows activity against influenza viruses, rhabdovirus VSV, bunyavirus LACV, Thogoto virus, measles virus, Hantaan virus, Coxsackie virus CVB, Rift Valley fever virus RVFV, hepatitis B virus HBV, and Crimean- Congo hemorrhagic fever virus CCHFV. Belongs to the dynamin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Hydrolase

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: cytoplasm; cytosol; nuclear membrane; perinuclear region of cytoplasm

Molecular Function: protein binding

Biological Process: apoptosis; defense response; innate immune response; negative regulation of viral genome replication; response to virus; signal transduction