MRAP2 blocking peptide

MRAP2 Antibody (Center) Blocking Peptide

• Gene Names: MRAP2; BMIQ18; C6orf117; bA51G5.2
• Synonyms: MRAP2; MRAP2 Antibody (Center) Blocking Peptide; Melanocortin-2 receptor accessory protein 2; MC2R accessory protein 2; C6orf117; MRAP2 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of MRAP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 205

• Cellular Location: Cell membrane; Single-pass membrane protein Endoplasmic reticulum membrane; Single-pass membrane protein Note: The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context
• Tissue Location: Expressed in the adrenal gland and brain. Not expressed in other tissues.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MRAP2 blocking peptide

Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo.

NCBI and Uniprot Product Information

• NCBI GI #: 68565259
• NCBI GeneID: 112609
• UniProt Accession #: Q96G30; Q8IXM9; Q8N2D1; A8K9M1
• Molecular Weight: 23,548 Da
• NCBI Official Full Name: Melanocortin-2 receptor accessory protein 2
• NCBI Official Synonym Full Names: melanocortin 2 receptor accessory protein 2
• NCBI Official Symbol: MRAP2
• NCBI Official Synonym Symbols: BMIQ18; C6orf117; bA51G5.2
• NCBI Protein Information: melanocortin-2 receptor accessory protein 2
• UniProt Protein Name: Melanocortin-2 receptor accessory protein 2
• Protein Family: Melanocortin-2 receptor accessory protein
• UniProt Gene Name: MRAP2
• UniProt Synonym Gene Names: C6orf117; MC2R accessory protein 2
• UniProt Entry Name: MRAP2_HUMAN

Uniprot Description

MRAP2: Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP. May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo. Belongs to the MRAP family. Homodimer and heterodimer. Forms antiparallel homodimers and heterodimers with MRAP. Interacts with MC1R, MC2R, MC3R, MC4R and MC5R

Chromosomal Location of Human Ortholog: 6q14.2

Cellular Component: endoplasmic reticulum; plasma membrane

Molecular Function: adrenocorticotropin hormone receptor binding; identical protein binding; protein binding; type 3 melanocortin receptor binding; type 4 melanocortin receptor binding; type 5 melanocortin receptor binding

Biological Process: energy reserve metabolic process; feeding behavior; positive regulation of cAMP biosynthetic process

Disease: Body Mass Index Quantitative Trait Locus 18