MR1 blocking peptide

MR1 Antibody (C-term) Blocking Peptide

• Gene Names: MR1; HLALS
• Synonyms: MR1; MR1 Antibody (C-term) Blocking Peptide; Major histocompatibility complex class I-related gene protein; MHC class I-related gene protein; Class I histocompatibility antigen-like protein; MR1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 341

• Cellular Location: Cell membrane; Single-pass membrane protein; Extracellular side. Endoplasmic reticulum Isoform 3: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane. Note: The larger proportion remains in the ER in an immature state. The subset that reach cell surface does it through a B2M-independent pathway
• Tissue Location: Ubiquitous..
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MR1 blocking peptide

Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T- cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.

NCBI and Uniprot Product Information

• NCBI GI #: 74751679
• NCBI GeneID: 3140
• UniProt Accession #: Q95460; O97985; O97986; Q53GM1; Q95HB8; Q9MY23; Q9NPL2; Q9TQB3; Q9TQB9; Q9TQK3; A8K2V9; B4E3B1
• Molecular Weight: 25,190 Da
• NCBI Official Full Name: Major histocompatibility complex class I-related gene protein
• NCBI Official Synonym Full Names: major histocompatibility complex, class I-related
• NCBI Official Symbol: MR1
• NCBI Official Synonym Symbols: HLALS
• NCBI Protein Information: major histocompatibility complex class I-related gene protein
• UniProt Protein Name: Major histocompatibility complex class I-related gene protein
• Protein Family: Major histocompatibility complex class I-related gene protein
• UniProt Gene Name: MR1
• UniProt Synonym Gene Names: MHC class I-related gene protein
• UniProt Entry Name: HMR1_HUMAN

NCBI Description

MAIT (mucosal-associated invariant T-cells) lymphocytes represent a small population of T-cells primarily found in the gut. The protein encoded by this gene is an antigen-presenting molecule that presents metabolites of microbial vitamin B to MAITs. This presentation may activate the MAITs to regulate the amounts of specific types of bacteria in the gut. Several transcript variants encoding different isoforms have been found for this gene, and a pseudogene of it has been detected about 36 kbp upstream on the same chromosome. [provided by RefSeq, Jul 2015]

Uniprot Description

MR1: Has antigen presentation function. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand- dependent. Belongs to the MHC class I family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q25.3

Cellular Component: endoplasmic reticulum; plasma membrane

Molecular Function: antigen binding; MHC class I receptor activity; protein binding

Biological Process: antigen processing and presentation; immune response