MMP26 blocking peptide

MMP26 Blocking Peptide (Center)

• Synonyms: MMP26; MMP26 Blocking Peptide (Center); Matrix metalloproteinase-26; MMP-26; 3424-; Endometase; Matrilysin-2; MMP26 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 111-125 of HUMAN MMP26
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 261

• Cellular Location: Secreted, extracellular space, extracellular matrix
• Tissue Location: Expressed specifically in uterus and placenta. Is also widely expressed in malignant tumors from different sources as well as in diverse tumor cell lines
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MMP26 blocking peptide

May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B.

NCBI and Uniprot Product Information

• NCBI GI #: 73808266
• NCBI GeneID: 56547
• NCBI Accession #: NP_068573.2
• NCBI GenBank Nucleotide #: NM_021801.4
• UniProt Accession #: Q9NRE1; Q3MJ78; Q9GZS2; Q9NR87
• Molecular Weight: 29,708 Da
• NCBI Official Full Name: matrix metalloproteinase-26 preproprotein
• NCBI Official Synonym Full Names: matrix metallopeptidase 26
• NCBI Official Symbol: MMP26
• NCBI Protein Information: matrix metalloproteinase-26
• UniProt Protein Name: Matrix metalloproteinase-26
• Protein Family: Matrix metalloproteinase
• UniProt Gene Name: MMP26
• UniProt Synonym Gene Names: MMP-26
• UniProt Entry Name: MMP26_HUMAN

NCBI Description

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme may degrade collagen type IV, fibronectin, fibrinogen, and beta-casein, and activate matrix metalloproteinase-9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The encoded protein may promote cell invasion in multiple human cancers. [provided by RefSeq, May 2016]

Uniprot Description

MMP26: May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B. Belongs to the peptidase M10A family.

Protein type: EC 3.4.24.-; Protease; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11p15

Biological Process: negative regulation of inflammatory response