MGAT3 blocking peptide

MGAT3 Antibody (N-term) Blocking Peptide

• Gene Names: MGAT3; GNT3; GNT-III
• Synonyms: MGAT3; MGAT3 Antibody (N-term) Blocking Peptide; Beta-1;4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III; GNT-III; GlcNAc-T III; N-acetylglucosaminyltransferase III; GGNT3; MGAT3 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human MGAT3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 533

• Cellular Location: Golgi apparatus membrane; Single-pass type II membrane protein
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MGAT3 blocking peptide

It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.

NCBI and Uniprot Product Information

• NCBI GI #: 148539888
• NCBI GeneID: 4248
• NCBI Accession #: NP_002400
• NCBI GenBank Nucleotide #: NM_002409.4
• UniProt Accession #: Q09327; Q14CK5; Q6IC49; Q9UH32; A6NGD0
• Molecular Weight: 61,313 Da
• NCBI Official Full Name: beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
• NCBI Official Synonym Full Names: mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
• NCBI Official Symbol: MGAT3
• NCBI Official Synonym Symbols: GNT3; GNT-III
• NCBI Protein Information: beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
• UniProt Protein Name: Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
• Protein Family: Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
• UniProt Gene Name: MGAT3
• UniProt Synonym Gene Names: GGNT3; GNT-III; GlcNAc-T III; N-acetylglucosaminyltransferase III
• UniProt Entry Name: MGAT3_HUMAN

NCBI Description

There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

MGAT3: It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. Belongs to the glycosyltransferase 17 family.

Protein type: Transferase; Membrane protein, integral; EC 2.4.1.144; Glycan Metabolism - N-glycan biosynthesis

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: Golgi membrane

Molecular Function: beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity