Map3k1 blocking peptide
Mouse Map3k1 Antibody (C-term) Blocking Peptide
NCBI and Uniprot Product Information
Uniprot Description
MEKK1: a protein kinase of the STE11 family. Phosphorylates and activates MKK4 and -7, which in turn activate JNK1, -2 and -3. Contains 1 RING-type zinc finger. The RING finger domain of MEKK1 exhibits E3 ubiquitin ligase activity toward c-Jun. c-Jun is downregulated in response to osmotic stress via ubiquitination-mediated degradation by the RING finger domain of MEKK1. Overexpressed/overactivated in multiple tumor types. The Mek1/2 inhibitor U0126 blocks export of influenza viral particles and has been suggested as an antiviral treatment. Single mutations at the same point of each gene also associated with cardiofaciocutaneous syndrome, (also linked with Braf and Kras mutations), displaying morphological, cardiac and mental defects. Inhibitors: U0126, CI-1040/PD184352, PD-0325901 (Phase I cancer), ARRY-142886 (Phase 1, cancer).
Protein type: Kinase, protein; EC 2.7.11.25; Protein kinase, STE; Ubiquitin conjugating system; Protein kinase, Ser/Thr (non-receptor); Ubiquitin ligase; Ligase; STE group; STE11 family
Cellular Component: cell junction; cytoplasm; cytoskeleton; filamentous actin; membrane
Molecular Function: cytoskeletal protein binding; JUN kinase binding; JUN kinase kinase kinase activity; MAP kinase kinase kinase activity; mitogen-activated protein kinase binding; mitogen-activated protein kinase kinase binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; sphingolipid binding; ubiquitin-protein ligase activity
Biological Process: activation of JNK activity; apoptotic mitochondrial changes; camera-type eye development; JNK cascade; morphogenesis of an epithelial sheet; positive regulation of actin filament polymerization; regulation of cell migration; transforming growth factor beta receptor signaling pathway; wound healing
Research Articles on Map3k1
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Product Notes
The Map3k1 map3k1 (Catalog #AAA9220955) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Map3k1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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