MAGEA3 blocking peptide

MAGEA3 Antibody (C-term) Blocking Peptide

• Gene Names: MAGEA3; HIP8; HYPD; CT1.3; MAGE3; MAGEA6
• Synonyms: MAGEA3; MAGEA3 Antibody (C-term) Blocking Peptide; Melanoma-associated antigen 3; Antigen MZ2-D; Cancer/testis antigen 13; CT13; MAGE-3 antigen; MAGE3; MAGEA3 blocking peptide

• Specificity: The synthetic peptide sequence is selected from the C-terminus of human MAGEA3.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 314

• Tissue Location: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta. Never expressed in kidney tumors, Leukemias and lymphomas
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MAGEA3 blocking peptide

Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

NCBI and Uniprot Product Information

• NCBI GI #: 1170857
• NCBI GeneID: 4102
• UniProt Accession #: P43357; Q6FHI6
• Molecular Weight: 34,747 Da
• NCBI Official Full Name: Melanoma-associated antigen 3
• NCBI Official Synonym Full Names: MAGE family member A3
• NCBI Official Symbol: MAGEA3
• NCBI Official Synonym Symbols: HIP8; HYPD; CT1.3; MAGE3; MAGEA6
• NCBI Protein Information: melanoma-associated antigen 3
• UniProt Protein Name: Melanoma-associated antigen 3
• Protein Family: Melanoma-associated antigen
• UniProt Gene Name: MAGEA3
• UniProt Synonym Gene Names: MAGE3; CT1.3
• UniProt Entry Name: MAGA3_HUMAN

NCBI Description

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]

Uniprot Description

MAGEA3: Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

Protein type: Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: endoplasmic reticulum

Molecular Function: protein binding

Biological Process: negative regulation of caspase activity