LMO4 blocking peptide

LMO4 (E138) Peptide

Cat. Num. AAA3002065

• Applications: Blocking
• Purity: Synthetic peptide LMO4 (E138). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: LMO4; LMO4 (E138) Peptide; Cysteine-rich protein 3; CRP3; LIM domain protein. cardiac; Muscle LIM protein; CSRP3; CLP. CMD1M. CRP3. LMO4. MGC14488. MGC61993. MLP; LMO4 blocking peptide

• Specificity: This peptide can be used with studies using MBS3002064 LMO4 (E138) pAb.
• Purity/Purification: Synthetic peptide LMO4 (E138). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 165

• Applicable Applications for LMO4 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for LMO4 blocking peptide

The LIM-only (LMO) proteins, LMO1 and LMO2, are nuclear factors that are characterized by a conserved LIM domain. The LIM domain consists of a cysteine-rich zinc-binding motif that is present in a variety of transcription factors, including the LIM homeobox (LHX) proteins expressed in the central nervous system and involved in cell differentiation. LMO1 and LMO2 are expressed in the adult CNS in a cell type-specific manner, where they are differentially regulated by neuronal activity and are involved in regulating the cellular differentiated phenotype of neurons. LMO2 lacks a specific DNA-binding homeobox domain but rather assembles into transcriptional regulatory complexes to mediate gene expression by interacting with the widely expressed nuclear LIM interactor (NLI). NLI, known also as CLIM-1, and the related protein CLIM-2 facilitate the formation of heteromeric LIM complexes and also enhance the nuclear retention of LIM proteins. LMO2 and the related protein LMO4 are expressed in thymic precursor cells. LMO4 is also expressed in mature T cells, cranial neural crest cells, somite, dorsal limb bud mesenchyme, motor neurons, and Schwann cell progenitors.

NCBI and Uniprot Product Information

• NCBI GI #: 5803072
• NCBI GeneID: 8543
• NCBI Accession #: NP_006760.1
• NCBI GenBank Nucleotide #: NP_006760.1
• UniProt Accession #: P61968
• NCBI Official Full Name: LIM domain transcription factor LMO4
• NCBI Official Synonym Full Names: LIM domain only 4
• NCBI Official Symbol: LMO4
• NCBI Protein Information: LIM domain transcription factor LMO4
• UniProt Protein Name: LIM domain transcription factor LMO4
• Protein Family: LIM domain transcription factor
• UniProt Gene Name: LMO4
• UniProt Synonym Gene Names: LMO-4
• UniProt Entry Name: LMO4_HUMAN

NCBI Description

This gene encodes a cysteine-rich protein that contains two LIM domains but lacks a DNA-binding homeodomain. The encoded protein may play a role as a transcriptional regulator or as an oncogene. [provided by RefSeq, Aug 2008]

Uniprot Description

LMO4: Probable transcriptional factor.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 1p22.3

Cellular Component: transcription factor complex

Molecular Function: zinc ion binding; transcription factor activity; transcription factor binding

Biological Process: transcription from RNA polymerase II promoter; thymus development; ventral spinal cord interneuron differentiation; neural tube closure; regulation of cell activation; regulation of cell fate specification; spinal cord association neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; spinal cord motor neuron differentiation; negative regulation of protein complex assembly