LIME1 blocking peptide

LIME1 Antibody (C-term) Blocking Peptide

• Gene Names: LIME1; LIME; dJ583P15.4
• Synonyms: LIME1; LIME1 Antibody (C-term) Blocking Peptide; Lck-interacting transmembrane adapter 1; Lck-interacting membrane protein; Lck-interacting molecule; LIME; LIME1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 295

• Cellular Location: Cell membrane; Single-pass type III membrane protein. Note: Present in lipid rafts Recruited to the immunological synapse upon conjugation of T-cell with antigen-presenting cell
• Tissue Location: Expressed in peripheral blood lymphocytes, lymphoid tissues, and liver. Present in T-cells and plasma cells, and in various hematopoietic cell lines (at protein level)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for LIME1 blocking peptide

Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T- cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules.

NCBI and Uniprot Product Information

• NCBI GI #: 74752630
• NCBI GeneID: 54923
• UniProt Accession #: Q9H400; Q5JWJ2; Q6XYB3; Q9NX69; E1P5K5; E1P5K6
• Molecular Weight: 20,841 Da
• NCBI Official Full Name: Lck-interacting transmembrane adapter 1
• NCBI Official Synonym Full Names: Lck interacting transmembrane adaptor 1
• NCBI Official Symbol: LIME1
• NCBI Official Synonym Symbols: LIME; dJ583P15.4
• NCBI Protein Information: lck-interacting transmembrane adapter 1
• UniProt Protein Name: Lck-interacting transmembrane adapter 1
• Protein Family: Lck-interacting transmembrane adapter
• UniProt Gene Name: LIME1
• UniProt Synonym Gene Names: LIME; Lck-interacting membrane protein
• UniProt Entry Name: LIME1_HUMAN

NCBI Description

This gene encodes a transmembrane adaptor protein that links the T and B-cell receptor stimulation to downstream signaling pathways via its association with the Src family kinases Lck and Lyn, respectively. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2015]

Uniprot Description

LIME1: Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T- cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 20q13.3

Cellular Component: extracellular space