LASP1 blocking peptide

LASP1 Antibody (Center) Blocking Peptide

• Gene Names: LASP1; MLN50; Lasp-1
• Synonyms: LASP1; LASP1 Antibody (Center) Blocking Peptide; LIM and SH3 domain protein 1; LASP-1; Metastatic lymph node gene 50 protein; MLN 50; MLN50; LASP1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 261

• Cellular Location: Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note: Associated with the F- actin rich cortical cytoskeleton.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for LASP1 blocking peptide

Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 3122342
• NCBI GeneID: 3927
• UniProt Accession #: Q14847; Q96ED2; Q96IG0; B4DGQ0
• Molecular Weight: 23,181 Da
• NCBI Official Full Name: LIM and SH3 domain protein 1
• NCBI Official Synonym Full Names: LIM and SH3 protein 1
• NCBI Official Symbol: LASP1
• NCBI Official Synonym Symbols: MLN50; Lasp-1
• NCBI Protein Information: LIM and SH3 domain protein 1
• UniProt Protein Name: LIM and SH3 domain protein 1
• Protein Family: LIM and SH3 domain protein
• UniProt Gene Name: LASP1
• UniProt Synonym Gene Names: MLN50; LASP-1; MLN 50
• UniProt Entry Name: LASP1_HUMAN

NCBI Description

This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]

Uniprot Description

Lasp-1: a member of the LIM protein subfamily, characterized by a LIM motif and SH3 domain. Functions as an actin-binding protein, possibly in cytoskeletal organization.

Protein type: Motility/polarity/chemotaxis; Actin-binding

Chromosomal Location of Human Ortholog: 17q11-q21.3

Cellular Component: cortical actin cytoskeleton; focal adhesion

Molecular Function: ion transmembrane transporter activity; protein binding; SH3/SH2 adaptor activity

Biological Process: ion transport