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KRT86 blocking peptide

KRT86 Blocking Peptide (Center)

Gene Names
KRT83; K83; KRT81; Keratin-83
Synonyms
KRT86; KRT86 Blocking Peptide (Center); Keratin; type II cuticular Hb6; Hair keratin K211; Keratin-86; K86; Type II hair keratin Hb6; Type-II keratin Kb26; KRTHB6; KRT86 blocking peptide
Ordering
Specificity
The synthetic peptide sequence is selected from aa 315-327 of HUMAN KRT86
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
493
Tissue Location
Synthesis begins slightly higher in the hair shaft than HB1 and HB3 and continues much farther up, ending in the keratogeneous zone.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
54,195 Da
NCBI Official Full Name
Keratin, type II cuticular Hb3
NCBI Official Symbol
KRT83
NCBI Official Synonym Symbols
K83; KRT81; Keratin-83
NCBI Protein Information
keratin, type II cuticular Hb3
UniProt Protein Name
Keratin, type II cuticular Hb3
Protein Family
UniProt Gene Name
KRT83
UniProt Synonym Gene Names
KRTHB3; K83
UniProt Entry Name
KRT83_HUMAN

Uniprot Description

K83: Defects in KRT83 are a cause of monilethrix (MLTRX). Monilethrix is an autosomal dominant hair disorder characterized clinically by alopecia and follicular papules. Affected hairs have uniform elliptical nodes of normal thickness and intermittent constrictions, internodes at which the hair easily breaks. Usually only the scalp is involved, but in severe forms, the secondary sexual hair, eyebrows, eyelashes, and nails may also be affected. Belongs to the intermediate filament family.

Protein type: Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: extracellular space

Molecular Function: protein binding

Biological Process: aging; epidermis development; hair cycle

Disease: Monilethrix

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Product Notes

The KRT86 krt83 (Catalog #AAA9228823) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "KRT86, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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