Klf4 blocking peptide

Mouse Klf4 Blocking Peptide (C-term)

• Gene Names: Klf4; EZF; Zie; Gklf
• Synonyms: Klf4; Mouse Klf4 Blocking Peptide (C-term); Krueppel-like factor 4; Epithelial zinc finger protein EZF; Gut-enriched krueppel-like factor; Ezf; Gklf; Zie; Klf4 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 378-390 of HUMAN Klf4
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 483

• Cellular Location: Nucleus.
• Tissue Location: Highest expression in the colon. Lower levels in testis, lung and small intestine
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Klf4 blocking peptide

Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 223590253
• NCBI GeneID: 16600
• UniProt Accession #: Q60793; P70421; Q3U2D6; Q3URS6; Q78K30; Q9R255
• Molecular Weight: 51,880 Da
• NCBI Official Full Name: Krueppel-like factor 4
• NCBI Official Synonym Full Names: Kruppel-like factor 4 (gut)
• NCBI Official Symbol: Klf4
• NCBI Official Synonym Symbols: EZF; Zie; Gklf
• NCBI Protein Information: Krueppel-like factor 4
• UniProt Protein Name: Krueppel-like factor 4
• Protein Family: Krueppel-like factor
• UniProt Gene Name: Klf4
• UniProt Synonym Gene Names: Ezf; Gklf; Zie
• UniProt Entry Name: KLF4_MOUSE

Uniprot Description

KLF4: Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription. Interacts with POU5F1/OCT4 and SOX2. Interacts with MUC1 (via the C-terminal domain). Belongs to the krueppel C2H2-type zinc-finger protein family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor

Cellular Component: chromatin; cytoplasm; nuclear chromatin; nucleoplasm; nucleus; transcription factor complex

Molecular Function: beta-catenin binding; DNA binding; double-stranded DNA binding; histone deacetylase binding; phosphoinositide 3-kinase regulator activity; protein binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding

Biological Process: cell differentiation; epidermal cell differentiation; epidermis morphogenesis; fat cell differentiation; inhibition of NF-kappaB transcription factor; negative regulation of caspase activity; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of heterotypic cell-cell adhesion; negative regulation of interleukin-8 biosynthetic process; negative regulation of muscle hyperplasia; negative regulation of phosphoinositide 3-kinase cascade; negative regulation of protein kinase B signaling cascade; negative regulation of smooth muscle cell proliferation; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of cellular protein metabolic process; positive regulation of hemoglobin biosynthetic process; positive regulation of nitric oxide biosynthetic process; positive regulation of protein metabolic process; positive regulation of telomerase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; post-embryonic camera-type eye development; post-embryonic hemopoiesis; regulation of axon regeneration; regulation of cell differentiation; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; response to organic substance; response to retinoic acid; stem cell maintenance; transcription from RNA polymerase II promoter; transcription, DNA-dependent; Wnt receptor signaling pathway through beta-catenin