KIDINS220 blocking peptide

KIDINS220 Antibody (C-term) Blocking Peptide

• Gene Names: KIDINS220; ARMS
• Synonyms: KIDINS220; KIDINS220 Antibody (C-term) Blocking Peptide; Kinase D-interacting substrate of 220 kDa; Ankyrin repeat-rich membrane-spanning protein; ARMS; KIAA1250; KIDINS220 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1771

• Cellular Location: Membrane; Multi-pass membrane protein. Late endosome. Note: Localized at late endosome before or after nerve growth factor (NGF) stimulation
• Tissue Location: Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells Overexpressed in melanoma and melanoma cell lines
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for KIDINS220 blocking peptide

Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)- induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress- induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.

NCBI and Uniprot Product Information

• NCBI GI #: 172044825
• NCBI GeneID: 57498
• UniProt Accession #: Q9ULH0; Q4VC08; Q6MZU2; Q9H889; Q9H9E4; Q9NT37; Q9UF42; A1L4N4
• Molecular Weight: 59,967 Da
• NCBI Official Full Name: Kinase D-interacting substrate of 220 kDa
• NCBI Official Synonym Full Names: kinase D-interacting substrate 220kDa
• NCBI Official Symbol: KIDINS220
• NCBI Official Synonym Symbols: ARMS
• NCBI Protein Information: kinase D-interacting substrate of 220 kDa
• UniProt Protein Name: Kinase D-interacting substrate of 220 kDa
• Protein Family: Kinase D-interacting substrate
• UniProt Gene Name: KIDINS220
• UniProt Synonym Gene Names: ARMS; KIAA1250
• UniProt Entry Name: KDIS_HUMAN

Uniprot Description

KIDINS220: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin- mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration. Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 2p24

Cellular Component: cytosol; late endosome; membrane; protein complex

Molecular Function: PDZ domain binding; protein kinase regulator activity

Biological Process: activation of MAPKK activity; regulation of protein kinase activity