IPMK blocking peptide

IPMK Blocking Peptide

Cat. Num. AAA9623537

• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: IPMK; IPMK Blocking Peptide; 3; 4; 6-tetrakisphosphate 5-kinase; Inositol 1; 6 tetrakisphosphate 5 kinase; Inositol polyphosphate multikinase; Ipmk; IPMK_HUMAN; IPMK blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for IPMK blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for IPMK blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 22726201
• NCBI GeneID: 253430
• NCBI Accession #: NP_689416.1
• NCBI GenBank Nucleotide #: NM_152230.4
• UniProt Accession #: Q8NFU5
• Molecular Weight: 47,222 Da
• NCBI Official Full Name: inositol polyphosphate multikinase
• NCBI Official Synonym Full Names: inositol polyphosphate multikinase
• NCBI Official Symbol: IPMK
• NCBI Protein Information: inositol polyphosphate multikinase; inositol 1,3,4,6-tetrakisphosphate 5-kinase
• UniProt Protein Name: Inositol polyphosphate multikinase
• Protein Family: Inositol polyphosphate multikinase
• UniProt Gene Name: IPMK
• UniProt Synonym Gene Names: IMPK
• UniProt Entry Name: IPMK_HUMAN

NCBI Description

This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of chromosome 19. [provided by RefSeq, Dec 2010]

Uniprot Description

IPMK: Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4). Belongs to the inositol phosphokinase (IPK) family.

Protein type: EC 2.7.1.151; Carbohydrate Metabolism - inositol phosphate; Kinase, other; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10q21.1

Cellular Component: nucleoplasm; nucleolus; nucleus

Molecular Function: inositol tetrakisphosphate 3-kinase activity; inositol trisphosphate 6-kinase activity; inositol trisphosphate 3-kinase activity; ATP binding

Biological Process: inositol phosphate metabolic process; neural tube formation; phosphorylation; inositol phosphate biosynthetic process