IL37 blocking peptide

IL37 Peptide

Cat. Num. AAA3006553

• Gene Names: IL37; FIL1; FIL1Z; IL-1H; IL-37; IL1F7; IL1H4; IL-1F7; IL-1H4; IL1RP1; IL-1RP1; FIL1(ZETA)
• Applications: Blocking
• Purity: Synthetic peptide IL37. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: IL37; IL37 Peptide; Interleukin-37; Interleukin 37; FIL1 zeta; IL-1X; Interleukin-1 family member 7; IL-1F7; Interleukin-1 homolog 4; IL-1H; IL-1H4; Interleukin-1 zeta; IL-1 zeta; Interleukin-1-related protein; IL-1RP1; Interleukin-23; IL-37; FIL1Z; IL1F7; IL1H4; IL1RP1; IL37 blocking peptide

• Specificity: This peptide can be used with studies using MBS3006552 IL37 pAb.
• Purity/Purification: Synthetic peptide IL37. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 192

• Applicable Applications for IL37 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for IL37 blocking peptide

IL-1 (Interleukin-1) is a cytokine responsible for initiating a variety of activities through the activation of transcription factors, NFkappaB and AP-1, thereby promoting host response to injury or infection. The IL-1 superfamily is comprised of several ligands and receptors. IL-1F7, also known as IL-1zeta, IL-1 homolog 4 (IL-1H4) or IL-1 related protein 1 (IL-1rp1), is a secreted ligand belonging to this superfamily. It is expressed in the cytoplasm of peripheral monocytic cells localizing to the inner surface of the plasma membrane and surrounding the nuclear membrane suggesting that IL-1F7 may play a role in immune regulation. Five isoforms exist for this protein due to alternative splicing and they are designated IL-1F7a through IL-1F7e. Isoform a has a distinct N-terminus while isoforms c-d are truncated. Isoform b is the mature functional isoform that binds to the IL-18Ralpha-chain and the IL-18 binding protein (IL-18BP) acting as an IL-18 antagonist. IL-1F7 is closely related to IL-1ra, sharing 36% sequence identity.

NCBI and Uniprot Product Information

• NCBI GI #: 27894302
• NCBI GeneID: 27178
• NCBI Accession #: NP_775297.1
• NCBI GenBank Nucleotide #: NP_775297.1
• UniProt Accession #: Q9NZH6
• NCBI Official Full Name: interleukin-37 isoform 5
• NCBI Official Synonym Full Names: interleukin 37
• NCBI Official Symbol: IL37
• NCBI Official Synonym Symbols: FIL1; FIL1Z; IL-1H; IL-37; IL1F7; IL1H4; IL-1F7; IL-1H4; IL1RP1; IL-1RP1; FIL1(ZETA)
• NCBI Protein Information: interleukin-37
• UniProt Protein Name: Interleukin-37
• Protein Family: Interleukin
• UniProt Gene Name: IL37
• UniProt Synonym Gene Names: FIL1Z; IL1F7; IL1H4; IL1RP1; IL-1F7; IL-1H; IL-1H4; IL-1 zeta; IL-1RP1; IL-37
• UniProt Entry Name: IL37_HUMAN

NCBI Description

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

IL37: Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. Belongs to the IL-1 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 2q12-q14.1

Cellular Component: nucleoplasm; extracellular space; cytoplasm; extracellular region; nucleolus; nucleus; cytosol

Molecular Function: interleukin-1 receptor binding; cytokine activity

Biological Process: cytokine and chemokine mediated signaling pathway; immune response; inflammatory response