IL26 blocking peptide

IL26 Antibody (Center) Blocking Peptide

• Gene Names: IL26; AK155; IL-26
• Synonyms: IL26; IL26 Antibody (Center) Blocking Peptide; Interleukin-26; IL-26; Protein AK155; AK155; IL26 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 171

• Cellular Location: Secreted.
• Tissue Location: Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells. Expressed in colonic T-cells including Th17 inflammatory T-cells; the expression is significantly increased in serum of patients with Crohn's disease (at protein level).
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for IL26 blocking peptide

May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.

NCBI and Uniprot Product Information

• NCBI GI #: 17366984
• NCBI GeneID: 55801
• UniProt Accession #: Q9NPH9
• Molecular Weight: 19,843 Da
• NCBI Official Full Name: Interleukin-26
• NCBI Official Synonym Full Names: interleukin 26
• NCBI Official Symbol: IL26
• NCBI Official Synonym Symbols: AK155; IL-26
• NCBI Protein Information: interleukin-26
• UniProt Protein Name: Interleukin-26
• Protein Family: Interleukin
• UniProt Gene Name: IL26
• UniProt Synonym Gene Names: AK155; IL-26
• UniProt Entry Name: IL26_HUMAN

NCBI Description

This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri. [provided by RefSeq, Jul 2008]

Uniprot Description

IL26: May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. Belongs to the IL-10 family.

Protein type: Cytokine; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: cytosol; extracellular space

Molecular Function: cytokine activity

Biological Process: cell-cell signaling; immune response; inflammatory response; negative regulation of epithelial cell proliferation; positive regulation of cytokine secretion; positive regulation of JAK-STAT cascade; positive regulation of protein kinase B signaling cascade; positive regulation of stress-activated MAPK cascade; positive regulation of transcription from RNA polymerase II promoter