IL17RB blocking peptide

IL17RB Antibody (Center) Blocking Peptide

• Gene Names: IL17RB; CRL4; EVI27; IL17BR; IL17RH1
• Synonyms: IL17RB; IL17RB Antibody (Center) Blocking Peptide; Interleukin-17 receptor B; IL-17 receptor B; IL-17RB; Cytokine receptor-like 4; IL-17 receptor homolog 1; IL-17Rh1; IL17Rh1; Interleukin-17B receptor; IL-17B receptor; CRL4; EVI27; IL17BR; IL17RB blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of human IL17RB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 502

• Cellular Location: Isoform 1: Cell membrane; Single-pass type I membrane protein
• Tissue Location: Expressed in several endocrine tissues, mostly in fetal and adult liver, kidney, pancreas, testis, colon, brain and small intestine; not detected in peripheral blood leukocytes, lymphoid organs, and most cell lines
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for IL17RB blocking peptide

Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.

NCBI and Uniprot Product Information

• NCBI GI #: 21263748
• NCBI GeneID: 55540
• UniProt Accession #: Q9NRM6; Q9BPZ0; Q9NRL4; Q9NRM5
• Molecular Weight: 31,773 Da
• NCBI Official Full Name: Interleukin-17 receptor B
• NCBI Official Synonym Full Names: interleukin 17 receptor B
• NCBI Official Symbol: IL17RB
• NCBI Official Synonym Symbols: CRL4; EVI27; IL17BR; IL17RH1
• NCBI Protein Information: interleukin-17 receptor B
• UniProt Protein Name: Interleukin-17 receptor B
• Protein Family: Interleukin-17 receptor
• UniProt Gene Name: IL17RB
• UniProt Synonym Gene Names: CRL4; EVI27; IL17BR; IL-17 receptor B; IL-17RB; IL-17Rh1; IL17Rh1; IL-17B receptor
• UniProt Entry Name: I17RB_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq, Jul 2008]

Uniprot Description

IL17RB: Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: interleukin-17 receptor activity

Biological Process: defense response