HLA-DOA blocking peptide

HLA-DOA Blocking Peptide (N-term)

• Gene Names: HLA-DOA; HLADZ; HLA-DNA; HLA-DZA
• Synonyms: HLA-DOA; HLA-DOA Blocking Peptide (N-term); HLA class II histocompatibility antigen; DO alpha chain; MHC DN-alpha; MHC DZ alpha; MHC class II antigen DOA; HLA-DNA; HLA-DZA; HLA-DOA blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 250

• Cellular Location: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note: Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments Heterotetramerization is necessary to exit the ER
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for HLA-DOA blocking peptide

Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.

NCBI and Uniprot Product Information

• NCBI GI #: 122210
• NCBI GeneID: 3111
• UniProt Accession #: P06340; Q58HU0; Q58HU1; Q5STC7; Q9TQC6; Q9TQC7; Q9TQC8; Q9TQC9; Q9TQD0; Q9TQD1; Q9TQD2; Q9TQD3
• Molecular Weight: 27,599 Da
• NCBI Official Full Name: HLA class II histocompatibility antigen, DO alpha chain
• NCBI Official Synonym Full Names: major histocompatibility complex, class II, DO alpha
• NCBI Official Symbol: HLA-DOA
• NCBI Official Synonym Symbols: HLADZ; HLA-DNA; HLA-DZA
• NCBI Protein Information: HLA class II histocompatibility antigen, DO alpha chain
• UniProt Protein Name: HLA class II histocompatibility antigen, DO alpha chain
• Protein Family: HLA class II histocompatibility antigen
• UniProt Gene Name: HLA-DOA
• UniProt Synonym Gene Names: HLA-DNA; HLA-DZA
• UniProt Entry Name: DOA_HUMAN

NCBI Description

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008]

Uniprot Description

HLA-DOA: Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM. Belongs to the MHC class II family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: lysosomal membrane; MHC class II protein complex; plasma membrane

Molecular Function: MHC class II receptor activity; protein binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; negative regulation of antigen processing and presentation of peptide antigen via MHC class II