HHLA2 blocking peptide

HHLA2 Antibody (N-term) Blocking Peptide

• Gene Names: HHLA2; B7y; B7H7; B7-H5; B7-H7
• Synonyms: HHLA2; HHLA2 Antibody (N-term) Blocking Peptide; HERV-H LTR-associating protein 2; Human endogenous retrovirus-H long terminal repeat-associating protein 2; HHLA2 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 414

• Cellular Location: Membrane; Single-pass type I membrane protein
• Tissue Location: Expressed at high levels in colon, kidney, testis, lung and pancreas, and at lower levels in small intestine, liver and skeletal muscle. In immune cells, highly expressed in B- cells, dendritic cells and macrophages. Not detected in T-cells
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for HHLA2 blocking peptide

Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.

NCBI and Uniprot Product Information

• NCBI GI #: 5901964
• NCBI GeneID: 11148
• NCBI Accession #: NP_009003.1
• NCBI GenBank Nucleotide #: NM_007072.3
• UniProt Accession #: Q9UM44; Q9NWQ6; B4DKN2; D3DN60
• Molecular Weight: 39,614 Da
• NCBI Official Full Name: HERV-H LTR-associating protein 2 isoform a
• NCBI Official Synonym Full Names: HERV-H LTR-associating 2
• NCBI Official Symbol: HHLA2
• NCBI Official Synonym Symbols: B7y; B7H7; B7-H5; B7-H7
• NCBI Protein Information: HERV-H LTR-associating protein 2
• UniProt Protein Name: HERV-H LTR-associating protein 2
• Protein Family: HERV-H LTR-associating protein
• UniProt Gene Name: HHLA2
• UniProt Entry Name: HHLA2_HUMAN

NCBI Description

This gene encodes a protein ligand found on the surface of monocytes. The encoded protein is thought to regulate cell-mediated immunity by binding to a receptor on T lymphocytes and inhibiting the proliferation of these cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Uniprot Description

HHLA2: Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. Up-regulated in antigen-presenting cells in response to inflammation. Induced in dendritic cells in response to IFNG, poly(I:C) or heat-killed Listeria monocytogenes (at protein level). Interacts with TMIGD2. 2 isoforms of the human protein are produced by alternative splicing

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q13.13

Molecular Function: protein binding

Biological Process: positive regulation of activated T cell proliferation; positive regulation of cytokine production; T cell costimulation