HDAC7 blocking peptide

HDAC7 Antibody (C-term) Blocking Peptide

• Gene Names: HDAC7; HD7; HD7A; HDAC7A
• Synonyms: HDAC7; HDAC7 Antibody (C-term) Blocking Peptide; Histone deacetylase 7; HD7; Histone deacetylase 7A; HD7a; HDAC7A; HDAC7 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human HDAC7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 991

• Cellular Location: Nucleus. Cytoplasm. Note: In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for HDAC7 blocking peptide

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene.

NCBI and Uniprot Product Information

• NCBI GI #: 169234807
• NCBI GeneID: 51564
• NCBI Accession #: NP_056216
• NCBI GenBank Nucleotide #: NM_015401.4
• UniProt Accession #: Q8WUI4; Q6P1W9; Q6W9G7; Q7Z4K2; Q7Z5I1; Q96K01; Q9BR73; Q9H7L0; Q9NW41; B3KY08; B4DWI0; B4E0Q5
• Molecular Weight: 66,187 Da
• NCBI Official Full Name: histone deacetylase 7 isoform a
• NCBI Official Synonym Full Names: histone deacetylase 7
• NCBI Official Symbol: HDAC7
• NCBI Official Synonym Symbols: HD7; HD7A; HDAC7A
• NCBI Protein Information: histone deacetylase 7
• UniProt Protein Name: Histone deacetylase 7
• UniProt Gene Name: HDAC7
• UniProt Synonym Gene Names: HDAC7A; HD7; HD7a
• UniProt Entry Name: HDAC7_HUMAN

NCBI Description

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565).