HCN1 blocking peptide

HCN1 Blocking Peptide

Gene Names

HCN1; BCNG1; HAC-2; BCNG-1; EIEE24

Applications

Blocking/Control

Purity

The purity is >90%,tested by HPLC and MS.

Synonyms

HCN1; HCN1 Blocking Peptide; BCNG-1; BCNG1; Brain cyclic nucleotide gated channel 1; Brain cyclic nucleotide-gated channel 1; HAC 2; HAC2; HCN1_HUMAN; Hyperpolarization activated cyclic nucleotide gated potassium channel 1; Potassium channel; voltage-gated; brain; 1; Potassium/sodium hyperpolarization activated cyclic nucleotide gated channel 1; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1; HCN1 blocking peptide

Ordering
Cat. Num. AAA9626489 For Research Use Only!

Purity/Purification

The purity is >90%,tested by HPLC and MS.

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

Applicable Applications for HCN1 blocking peptide

Blocking/Control

Notes

For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for HCN1 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

NCBI GI #

116325989

NCBI GeneID

348980

NCBI Accession #

NP_066550.2

NCBI GenBank Nucleotide #

NM_021072.3

UniProt Accession #

O60741

Molecular Weight

98,796 Da

NCBI Official Full Name

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

NCBI Official Synonym Full Names

hyperpolarization activated cyclic nucleotide-gated potassium channel 1

NCBI Official Symbol

HCN1

NCBI Official Synonym Symbols

BCNG1; HAC-2; BCNG-1; EIEE24

NCBI Protein Information

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1; brain cyclic nucleotide gated channel 1; brain cyclic nucleotide-gated channel 1

UniProt Protein Name

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

Protein Family

Anaphase-promoting complex

UniProt Gene Name

HCN1

UniProt Synonym Gene Names

BCNG1; BCNG-1

UniProt Entry Name

HCN1_HUMAN

NCBI Description

The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011]

Uniprot Description

HCN1: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. May mediate responses to sour stimuli. Belongs to the potassium channel HCN family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5p12

Cellular Component: axon; integral to plasma membrane; dendrite; integral to membrane; plasma membrane

Molecular Function: identical protein binding; voltage-gated potassium channel activity; intracellular cAMP activated cation channel activity; potassium channel activity; voltage-gated sodium channel activity; cAMP binding

Biological Process: synaptic transmission; regulation of membrane potential; apical protein localization; retinal cone cell development; potassium ion transport

Disease: Epileptic Encephalopathy, Early Infantile, 24

Research Articles on HCN1

1. de novo HCN1 point mutations cause a recognizable early-onset epileptic encephalopathy in humans

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Product Notes

The HCN1 hcn1 (Catalog #AAA9626489) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's HCN1 can be used in a range of immunoassay formats including, but not limited to, Blocking/Control. Researchers should empirically determine the suitability of the HCN1 hcn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HCN1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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HCN1 blocking peptide