GPR119 blocking peptide

GPR119 Blocking Peptide

Cat. Num. AAA9625061

• Gene Names: GPR119; GPCR2
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: GPR119; GPR119 Blocking Peptide; G protein coupled receptor 119; G protein coupled receptor 2; G-protein coupled receptor 119; Glucose dependent insulinotropic receptor; Glucose-dependent insulinotropic receptor; GP119_HUMAN; GPCR 2; GPCR2; GPR 119; Gpr119; HGPCR 2; HGPCR2; MGC119957; Seven transmembrane helix receptor; GPR119 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for GPR119 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for GPR119 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 30425400
• NCBI GeneID: 139760
• NCBI Accession #: NP_848566.1
• NCBI GenBank Nucleotide #: NM_178471.2
• UniProt Accession #: Q8TDV5; Q495H7; Q4VBN3
• Molecular Weight: 36,889 Da
• NCBI Official Full Name: glucose-dependent insulinotropic receptor
• NCBI Official Synonym Full Names: G protein-coupled receptor 119
• NCBI Official Symbol: GPR119
• NCBI Official Synonym Symbols: GPCR2
• NCBI Protein Information: glucose-dependent insulinotropic receptor; G-protein coupled receptor 2
• UniProt Protein Name: Glucose-dependent insulinotropic receptor
• Protein Family: Glucose-dependent insulinotropic receptor
• UniProt Gene Name: GPR119
• UniProt Entry Name: GP119_HUMAN

NCBI Description

This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.[provided by RefSeq, Jan 2010]

Uniprot Description

GPR119: Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq26.1

Cellular Component: integral to membrane; plasma membrane; receptor complex

Molecular Function: G-protein coupled receptor activity; phosphatidylcholine binding

Biological Process: G-protein coupled receptor protein signaling pathway; insulin secretion