GPR119 blocking peptide

GPR119 (V227) Peptide

Cat. Num. AAA3002839

• Gene Names: GPR119; GPCR2
• Applications: Blocking
• Purity: Synthetic peptide GPR119 (V227). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: GPR119; GPR119 (V227) Peptide; GPCR2; hGPCR2; MGC119957; GPR119 blocking peptide

• Specificity: This peptide can be used with studies using MBS3002838 GPR119 (V227) pAb.
• Purity/Purification: Synthetic peptide GPR119 (V227). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 335

• Applicable Applications for GPR119 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for GPR119 blocking peptide

G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intra cellular signal (G protein activation). GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. All of the receptors have seven membrane- spanning domains and the extracellular parts of the receptor can be glycosylated. These extracellular loops also contain two highly conserved cysteine residues which create disulfide bonds to stabilize the receptor structure. GPR119 is a 335 amino acid protein that is mainly expressed in the pancreas. It is an endogenous receptor for lysophosphatidylcholine (LPC), which is is a lipid mediator involved in insulin secretion from pancreatic ? cells. GPR119 may participate in this insulin secretion, suggesting that it may be potential target for new anti-diabetic drugs.

NCBI and Uniprot Product Information

• NCBI GI #: 30425400
• NCBI GeneID: 139760
• NCBI Accession #: NP_848566.1
• NCBI GenBank Nucleotide #: NP_848566.1
• UniProt Accession #: Q8TDV5
• NCBI Official Full Name: glucose-dependent insulinotropic receptor
• NCBI Official Synonym Full Names: G protein-coupled receptor 119
• NCBI Official Symbol: GPR119
• NCBI Official Synonym Symbols: GPCR2
• NCBI Protein Information: glucose-dependent insulinotropic receptor
• UniProt Protein Name: Glucose-dependent insulinotropic receptor
• Protein Family: Glucose-dependent insulinotropic receptor
• UniProt Gene Name: GPR119
• UniProt Entry Name: GP119_HUMAN

NCBI Description

This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.[provided by RefSeq, Jan 2010]

Uniprot Description

GPR119: Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq26.1

Cellular Component: integral to membrane; plasma membrane; receptor complex

Molecular Function: G-protein coupled receptor activity; phosphatidylcholine binding

Biological Process: G-protein coupled receptor protein signaling pathway; insulin secretion