GLUT2 blocking peptide

GLUT2 Blocking Peptide

Cat. Num. AAA9628963

• Gene Names: SLC2A2; GLUT2
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: GLUT2; GLUT2 Blocking Peptide; liver; Glucose Transporter 2; Glucose Transporter GLUT2; Glucose transporter type 2; Glucose transporter type 2 liver; Glucose transporter; liver/islet; GLUT-2; GTR2_HUMAN; GTT2; SLC2A2; Solute carrier family 2 (facilitated glucose transporter) member 2; Solute carrier family 2 facilitated glucose transporter member 2; Solute carrier family 2; facilitated glucose transporter member 2; GLUT2 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for GLUT2 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for GLUT2 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 4557851
• NCBI GeneID: 6514
• NCBI Accession #: NP_000331.1
• NCBI GenBank Nucleotide #: NM_000340.1
• UniProt Accession #: P11168; Q9UCW9; A8K481; B2R936; B7Z547; F8W8V8
• Molecular Weight: 44,702 Da
• NCBI Official Full Name: solute carrier family 2, facilitated glucose transporter member 2 isoform 1
• NCBI Official Synonym Full Names: solute carrier family 2 member 2
• NCBI Official Symbol: SLC2A2
• NCBI Official Synonym Symbols: GLUT2
• NCBI Protein Information: solute carrier family 2, facilitated glucose transporter member 2
• UniProt Protein Name: Solute carrier family 2, facilitated glucose transporter member 2
• UniProt Gene Name: SLC2A2
• UniProt Synonym Gene Names: GLUT2; GLUT-2
• UniProt Entry Name: GTR2_HUMAN

NCBI Description

This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Uniprot Description

GLUT2: an integral membrane facilitative glucose transporter. One of 13 members of the human equilibrative glucose transport protein family. Present at high levels in the plasma membrane of pancreatic b-cells where it initiates the first step in glucose-stimulated insulin secretion, a glucose metabolism-dependent signaling mechanism. May mediate the bidirectional transfer of glucose across the plasma membrane of hepatocytes. May also participate with the Na( +2)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Required for glucose sensitivity in the hypothalamus and brain stem. Involved in the control of food intake and stimulation of glucose uptake by peripheral tissues.

Protein type: Transporter, SLC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3q26.1-q26.2

Cellular Component: apical plasma membrane; basolateral plasma membrane; brush border membrane; cytosol; endosome; integral to plasma membrane; intercellular junction; membrane; plasma membrane

Molecular Function: D-glucose transmembrane transporter activity; dehydroascorbic acid transporter activity; glucose transmembrane transporter activity; hexose transmembrane transporter activity; insulin receptor binding

Biological Process: carbohydrate metabolic process; carbohydrate utilization; fructose transport; glucose transport; hexose transport; regulation of insulin secretion; response to glucose stimulus; response to peptide hormone stimulus

Disease: Diabetes Mellitus, Noninsulin-dependent; Fanconi-bickel Syndrome