FYB blocking peptide

FYB Antibody (C-term) Blocking peptide

• Gene Names: FYB; ADAP; PRO0823; SLAP130; SLAP-130
• Synonyms: FYB; FYB Antibody (C-term) Blocking peptide; FYN-binding protein; Adhesion and degranulation promoting adaptor protein; ADAP; FYB-120/130; p120/p130; FYN-T-binding protein; SLAP-130; SLP-76-associated phosphoprotein; SLAP130; FYB blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 783

• Cellular Location: Cytoplasm. Nucleus
• Tissue Location: Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for FYB blocking peptide

Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton.

NCBI and Uniprot Product Information

• NCBI GI #: 269849599
• NCBI GeneID: 2533
• UniProt Accession #: O15117; O00359; Q9NZI9; A8K2Y8; B4DLN2; E9PBV9
• Molecular Weight: 91,651 Da
• NCBI Official Full Name: FYN-binding protein
• NCBI Official Synonym Full Names: FYN binding protein
• NCBI Official Symbol: FYB
• NCBI Official Synonym Symbols: ADAP; PRO0823; SLAP130; SLAP-130
• NCBI Protein Information: FYN-binding protein
• UniProt Protein Name: FYN-binding protein
• Protein Family: FYN-binding protein
• UniProt Gene Name: FYB
• UniProt Synonym Gene Names: SLAP130; ADAP; p120/p130
• UniProt Entry Name: FYB_HUMAN

NCBI Description

The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

Uniprot Description

SLAP-130: an adapter protein for fyn and the SH2-domain-containing leucocyte protein-76 (SLP76) in T cells. T-cell receptor ligation leads to increased tyrosine phosphorylation of SLAP-130. Two alternatively spliced isoforms have been described.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 5p13.1

Cellular Component: actin cytoskeleton; cytosol

Molecular Function: protein binding; receptor binding

Biological Process: NLS-bearing substrate import into nucleus; protein amino acid phosphorylation; signal transduction; T cell receptor signaling pathway