FGFR3 blocking peptide

FGFR3 Peptide

Cat. Num. AAA543686

• Gene Names: FGFR2; BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM
• Applications: Immunodepletion, Immunocompetition
• Synonyms: FGFR3; FGFR3 Peptide; ACH; CD 333; CD333 antigen; CEK 2; FGFR 3; Fibroblast growth factor receptor 3 (achondroplasia thanatophoric dwarfism); Fibroblast growth factor receptor 3; Heparin binding growth factor receptor; HSFGFR3EX; Hydroxyaryl protein kinase; JTK 4; MFR 3; SAM 3; Tyrosine kinase JTK 4; Z FGFR 3 antibody; FGFR3 blocking peptide

• Form/Format: Antigenic Blocking Peptide
• Concentration: Quantity: 250 ug; Volume: 100 ul (varies by lot)
• Sequence Length: 480

• Applicable Applications for FGFR3 blocking peptide: Immunodepletion, Immunocompetition
• Application Notes: Western Blot: 1:500
• Immunogen: Synthetic peptide taken within amino acid region 400-450 on human FGFR3 protein.
• Expression: Expressed in brain, kidney and testis. Very low or no expression in spleen, heart, and muscle. In 20- to 22-week old fetuses it is expressed at high level in kidney, lung, small intestine and brain, and to a lower degree in spleen, liver, and muscle. Isoform 2 is detected in epithelial cells. Isoform 1 is not detected in epithelial cells. Isoform 1 and isoform 2 are detected in fibroblastic cells.
• Molecular Function: ATP-binding; Fibroblast growth factor binding; Heparin binding; Protein Tyrosine Kinase activity
• Structure: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.; Contains 3 Ig-like C2-type (immunoglobulin-like) domains.; Contains 1 protein kinase domain.
• Subcellular Location: Isoform 1 : Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Endoplasmic Reticulum; Note: The activated receptor is rapidly internalized and degraded. Detected in intracellular vesicles after internalization of the autophosphorylated receptor.; Isoform 2 : Cell membrane By similarity; Single-pass type I membrane protein By similarity; Isoform 3 : Secreted; Isoform 4 : Cell membrane By similarity; Single-pass type I membrane protein
• Preparation and Storage: -20 degree C for long term storage

Related Product Information for FGFR3 blocking peptide

Antigenic Blocking Peptide Fibroblast Growth Factor Receptor 3
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1, 4, 5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling.

NCBI and Uniprot Product Information

• NCBI GI #: 767962153
• NCBI GeneID: 2263
• NCBI Accession #: XP_011537812.1
• NCBI GenBank Nucleotide #: XM_011539510.1
• UniProt Accession #: A8E633; P21802
• Molecular Weight: 52,756 Da
• NCBI Official Synonym Full Names: fibroblast growth factor receptor 2
• NCBI Official Symbol: FGFR2
• NCBI Official Synonym Symbols: BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM
• NCBI Protein Information: fibroblast growth factor receptor 2
• UniProt Protein Name: FGFR3 protein
• Protein Family: Fibroblast growth factor receptor
• UniProt Gene Name: FGFR3
• UniProt Entry Name: A8E633_HUMAN

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]