FBXO43 blocking peptide

FBXO43 Blocking Peptide (C-term)

Gene Names

FBXO43; EMI2; ERP1; FBX43

Synonyms

FBXO43; FBXO43 Blocking Peptide (C-term); F-box only protein 43; Endogenous meiotic inhibitor 2; EMI2; FBXO43 blocking peptide

Ordering

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Sequence Length

708

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for FBXO43 blocking peptide

Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable).

NCBI and Uniprot Product Information

NCBI GI #

152031603

NCBI GeneID

286151

UniProt Accession #

Q4G163

Molecular Weight

78,402 Da

NCBI Official Full Name

F-box only protein 43

NCBI Official Synonym Full Names

F-box protein 43

NCBI Official Symbol

FBXO43

NCBI Official Synonym Symbols

EMI2; ERP1; FBX43

NCBI Protein Information

F-box only protein 43

UniProt Protein Name

F-box only protein 43

Protein Family

F-box only protein

UniProt Gene Name

FBXO43

UniProt Synonym Gene Names

EMI2

UniProt Entry Name

FBX43_HUMAN

NCBI Description

Members of the F-box protein family, such as FBXO43, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Uniprot Description

FBX43: Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable). Part of a SCF (SKP1-cullin-F-box) protein ligase complex. May interact with CDC20.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 8q22.2

Cellular Component: nucleus

Biological Process: negative regulation of meiosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of mitosis

Research Articles on FBXO43

1. Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition

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Product Notes

The FBXO43 fbxo43 (Catalog #AAA9229013) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "FBXO43, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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FBXO43 blocking peptide