FARP1 blocking peptide

FARP1 Antibody (N-term) Blocking Peptide

• Gene Names: FARP1; CDEP; PLEKHC2; PPP1R75; FARP1-IT1
• Synonyms: FARP1; FARP1 Antibody (N-term) Blocking Peptide; FERM; RhoGEF and pleckstrin domain-containing protein 1; Chondrocyte-derived ezrin-like protein; Pleckstrin homology domain-containing family C member 2; PH domain-containing family C member 2; CDEP; PLEKHC2; FARP1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1045

• Cellular Location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell junction, synapse, synaptosome. Cytoplasm, cytosol. Cell projection, filopodium. Cell projection, dendrite. Cell projection, dendritic spine Note: Recruited to the cell membrane via interaction with CADM1
• Tissue Location: Detected in cAMP-treated chondrocytes, but not in untreated chondrocytes. Detected in fetal brain, heart and spleen, and in adult testis, kidney and lung
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for FARP1 blocking peptide

Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 74762059
• NCBI GeneID: 10160
• UniProt Accession #: Q9Y4F1; Q5JVI9; Q6IQ29
• Molecular Weight: 14,138 Da
• NCBI Official Full Name: FERM, RhoGEF and pleckstrin domain-containing protein 1
• NCBI Official Synonym Full Names: FERM, ARH/RhoGEF and pleckstrin domain protein 1
• NCBI Official Symbol: FARP1
• NCBI Official Synonym Symbols: CDEP; PLEKHC2; PPP1R75; FARP1-IT1
• NCBI Protein Information: FERM, RhoGEF and pleckstrin domain-containing protein 1
• UniProt Protein Name: FERM, RhoGEF and pleckstrin domain-containing protein 1
• Protein Family: FERM, RhoGEF and pleckstrin domain-containing protein
• UniProt Gene Name: FARP1
• UniProt Synonym Gene Names: CDEP; PLEKHC2; PH domain-containing family C member 2
• UniProt Entry Name: FARP1_HUMAN

NCBI Description

This gene encodes a protein containing a FERM (4.2, exrin, radixin, moesin) domain, a Dbl homology domain, and two pleckstrin homology domains. These domains are found in guanine nucleotide exchange factors and proteins that link the cytoskeleton to the cell membrane. The encoded protein functions in neurons to promote dendritic growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

Uniprot Description

FARP1: May function as Rho-guanine nucleotide exchange factor. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs, Rac/Rho; GEFs; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 13q32.2

Cellular Component: cytoplasm; cytosol; dendrite; extrinsic to internal side of plasma membrane

Molecular Function: Rac guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity

Biological Process: dendrite morphogenesis; synaptogenesis