ENPP3 blocking peptide

ENPP3 Blocking Peptide(C-term)

• Gene Names: ENPP3; B10; NPP3; PDNP3; CD203c; PD-IBETA
• Synonyms: ENPP3; ENPP3 Blocking Peptide(C-term); Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; E-NPP 3; Phosphodiesterase I beta; PD-Ibeta; Phosphodiesterase I/nucleotide pyrophosphatase 3; CD203c; Alkaline phosphodiesterase I; Nucleotide pyrophosphatase; NPPase; PDNP3; ENPP3 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 829-843 of HUMAN ENPP3
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 875

• Cellular Location: Membrane; Single-pass type II membrane protein. Secreted Note: Located to the apical surface in intestinal and kidney epithelial cells. Located to the cell surface of basophils, and to the apical plasma membrane of bile duct cells. Secreted in serum, and in lumen of epithelial cells
• Tissue Location: Expressed in bile ducts, prostate, uterus and colon. Exclusively expressed on basophils, mast cells and their progenitors.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ENPP3 blocking peptide

Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD.

NCBI and Uniprot Product Information

• NCBI GI #: 111160296
• NCBI GeneID: 5169
• NCBI Accession #: NP_005012.2
• NCBI GenBank Nucleotide #: NM_005021.4
• UniProt Accession #: O14638; Q5JTL3
• Molecular Weight: 100,124 Da
• NCBI Official Full Name: ectonucleotide pyrophosphatase/phosphodiesterase family member 3
• NCBI Official Synonym Full Names: ectonucleotide pyrophosphatase/phosphodiesterase 3
• NCBI Official Symbol: ENPP3
• NCBI Official Synonym Symbols: B10; NPP3; PDNP3; CD203c; PD-IBETA
• NCBI Protein Information: ectonucleotide pyrophosphatase/phosphodiesterase family member 3
• UniProt Protein Name: Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
• Protein Family: Ectonucleotide pyrophosphatase/phosphodiesterase family
• UniProt Gene Name: ENPP3
• UniProt Synonym Gene Names: PDNP3; E-NPP 3; PD-Ibeta; NPPase
• UniProt Entry Name: ENPP3_HUMAN

NCBI Description

The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Oct 2015]

Uniprot Description

ENPP3: Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD. Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.

Protein type: Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; Motility/polarity/chemotaxis; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Phosphodiesterase; EC 3.6.1.9; Cofactor and Vitamin Metabolism - riboflavin; EC 3.1.4.1; Nucleotide Metabolism - purine; Membrane protein, integral; Carbohydrate Metabolism - starch and sucrose

Chromosomal Location of Human Ortholog: 6q22

Cellular Component: integral to plasma membrane; perinuclear region of cytoplasm

Molecular Function: nucleoside-triphosphate diphosphatase activity; nucleotide diphosphatase activity

Biological Process: inorganic diphosphate transport; nucleoside triphosphate catabolic process; phosphate metabolic process