ELAVL3 blocking peptide

ELAVL3 Antibody (N-term) Blocking peptide

• Gene Names: ELAVL3; HUC; HUCL; PLE21
• Synonyms: ELAVL3; ELAVL3 Antibody (N-term) Blocking peptide; ELAV-like protein 3; Hu-antigen C; HuC; Paraneoplastic cerebellar degeneration-associated antigen; Paraneoplastic limbic encephalitis antigen 21; HUC; PLE21; ELAVL3 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of ELAVL3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 367

• Tissue Location: Brain specific.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ELAVL3 blocking peptide

Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance.

NCBI and Uniprot Product Information

• NCBI GI #: 21264436
• NCBI GeneID: 1995
• UniProt Accession #: Q14576; Q16135; Q96CL8; Q96QS9
• Molecular Weight: 38,865 Da
• NCBI Official Full Name: ELAV-like protein 3
• NCBI Official Synonym Full Names: ELAV like neuron-specific RNA binding protein 3
• NCBI Official Symbol: ELAVL3
• NCBI Official Synonym Symbols: HUC; HUCL; PLE21
• NCBI Protein Information: ELAV-like protein 3
• UniProt Protein Name: ELAV-like protein 3
• Protein Family: ELAV-like protein
• UniProt Gene Name: ELAVL3
• UniProt Synonym Gene Names: HUC; PLE21; HuC
• UniProt Entry Name: ELAV3_HUMAN

NCBI Description

A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

ELAVL3: Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3. May be involved in neuronal differentiation and maintenance. Belongs to the RRM elav family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19p13.2

Molecular Function: AU-rich element binding