eIF5A2 blocking peptide

eIF5A2 (Y127) Peptide

Cat. Num. AAA3012292

• Gene Names: EIF5A2; EIF-5A2; eIF5AII
• Applications: Blocking
• Purity: Synthetic peptide eIF5A2 (Y127). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: eIF5A2; eIF5A2 (Y127) Peptide; Eukaryotic translation initiation factor 5A-2; eIF-5A-2; eIF-5A2; Eukaryotic initiation factor 5A isoform 2; EIF5A2; eIF5A2 blocking peptide

• Specificity: This peptide can be used with studies using MBS3012281 eIF5A2 (Y127) pAb.
• Purity/Purification: Synthetic peptide eIF5A2 (Y127). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 153

• Applicable Applications for eIF5A2 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for eIF5A2 blocking peptide

In mammalian cells, translation is controlled at the level of polypeptide chain initiation by eukaryotic initiation factors. The translation initiation factor 5 (eIF5) catalyzes the hydrolysis of GTP bound to the 40S ribosomal subunit, a function necessary for the subsequent joining of the 40S and 60S subunits to form the 80S initiation complex. eIF4E specifically binds to the mRNA cap to promote unwinding and exposure of the AUG-initiation codon. Overexpression of eIF4E can lead to cell transformation and tumorigenesis. An additional initiation factor, eIF2, is present as a heterotrimer composed of eIF2alpha, eIF2beta and eIF2gamma subunits. This heterotrimer forms a complex with GTP and tRNA which then binds to the 40S ribosomal subunit. After the formation of the 80S initiation complex, eIF2 is hydrolyzed and eIF2-GDP is released from the complex. eIF2-GDP is subsequently converted to eIF2-GTP, a reaction catalyzed by eIF2B, and is then available to catalyze another round of initiation.

NCBI and Uniprot Product Information

• NCBI GI #: 9966867
• NCBI GeneID: 56648
• NCBI Accession #: NP_065123.1
• NCBI GenBank Nucleotide #: NP_065123.1
• UniProt Accession #: Q9GZV4
• NCBI Official Full Name: eukaryotic translation initiation factor 5A-2
• NCBI Official Synonym Full Names: eukaryotic translation initiation factor 5A2
• NCBI Official Symbol: EIF5A2
• NCBI Official Synonym Symbols: EIF-5A2; eIF5AII
• NCBI Protein Information: eukaryotic translation initiation factor 5A-2
• UniProt Protein Name: Eukaryotic translation initiation factor 5A-2
• UniProt Gene Name: EIF5A2
• UniProt Synonym Gene Names: eIF-5A-2; eIF-5A2
• UniProt Entry Name: IF5A2_HUMAN

Uniprot Description

EIF5A2: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Belongs to the eIF-5A family.

Chromosomal Location of Human Ortholog: 3q26.2

Cellular Component: endoplasmic reticulum membrane; nuclear pore; cytosol

Molecular Function: protein binding; ribosome binding; translation elongation factor activity

Biological Process: protein transport; mRNA transport; translational frameshifting; cellular protein metabolic process; positive regulation of cell proliferation; positive regulation of translational elongation; spermatogenesis; hypusine biosynthetic process from peptidyl-lysine; polyamine homeostasis; post-translational protein modification; positive regulation of translational termination