Dyrk1a blocking peptide

Mouse Dyrk1a Antibody(C-term) Blocking peptide

• Gene Names: Dyrk1a; mmb; Dyrk; Mnbh; Mp86; Gm10783; D16Ertd272e; D16Ertd493e; 2310043O08Rik; ENSMUSG00000074897
• Synonyms: Dyrk1a; Mouse Dyrk1a Antibody(C-term) Blocking peptide; Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual specificity YAK1-related kinase; MP86; Protein kinase minibrain homolog; MNBH; Dyrk; Dyrk1a blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 763

• Cellular Location: Nucleus speckle
• Tissue Location: Detected in brain (at protein level). Expressed in a variety of embryonic and adult tissues. Expressed abundantly in neurons of the brain, spinal cord, and retina in developing embryos.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Dyrk1a blocking peptide

May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a sugstrate preference for proline at position P+1 and arginine at position P-3.

NCBI and Uniprot Product Information

• NCBI GI #: 6015042
• NCBI GeneID: 13548
• UniProt Accession #: Q61214
• Molecular Weight: 85,494 Da
• NCBI Official Full Name: Dual specificity tyrosine-phosphorylation-regulated kinase 1A
• NCBI Official Synonym Full Names: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a
• NCBI Official Symbol: Dyrk1a
• NCBI Official Synonym Symbols: mmb; Dyrk; Mnbh; Mp86; Gm10783; D16Ertd272e; D16Ertd493e; 2310043O08Rik; ENSMUSG00000074897
• NCBI Protein Information: dual specificity tyrosine-phosphorylation-regulated kinase 1A
• UniProt Protein Name: Dual specificity tyrosine-phosphorylation-regulated kinase 1A
• Protein Family: Dual specificity tyrosine-phosphorylation-regulated kinase
• UniProt Gene Name: Dyrk1a
• UniProt Synonym Gene Names: Dyrk; MNBH
• UniProt Entry Name: DYR1A_MOUSE

Uniprot Description

DYRK1A: a dual-specificity protein kinase of the DYRK family. Contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. May play a significant role in a pathway regulating cell proliferation and may be involved in brain development. Its gene is localized in the Down syndrome (DS) critical region of chromosome 21, and is a strong candidate gene for learning defects associated with Down syndrome. Overexpression in mice gives rise to neurological abnormalities similar to those observed in DS. Five splice-variant isoforms have been described.

Protein type: Kinase, protein; EC 2.7.12.2; Protein kinase, dual-specificity (non-receptor); Protein kinase, CMGC; CMGC group; DYRK family; Dyrk1 subfamily

Cellular Component: nuclear speck; nucleus; ribonucleoprotein complex

Molecular Function: identical protein binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein kinase activity; protein self-association; protein serine/threonine kinase activity; protein-tyrosine kinase activity; tau protein binding

Biological Process: circadian rhythm; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of nuclear mRNA splicing, via spliceosome; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of alternative nuclear mRNA splicing, via spliceosome