DULLARD blocking peptide
DULLARD Peptide - middle region
NCBI and Uniprot Product Information
Uniprot Description
Function: Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling. Ref.7 Ref.8
Catalytic activity: A phosphoprotein + H2O = a protein + phosphate.
Subunit structure: Interacts with CNEP1R1; the complex dephosphorylates LPIN1 and LPIN2. Ref.8
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein Ref.2 Ref.7 Ref.8.
Tissue specificity: Muscle specific with lower expression in other metabolic tissues. Ref.8
Sequence similarities: Belongs to the dullard family.Contains 1 FCP1 homology domain.
Biophysicochemical propertiesKinetic parameters:KM=18 mM for p-nitrophenylphosphate Ref.7pH dependence:Optimum pH is 5.5.
Research Articles on DULLARD
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Product Notes
The DULLARD ctdnep1 (Catalog #AAA3233406) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's DULLARD can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the DULLARD ctdnep1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DULLARD, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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