DRD1IP blocking peptide

DRD1IP Blocking Peptide

Cat. Num. AAA9627960

• Gene Names: CALY; NSG3; DRD1IP
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: DRD1IP; DRD1IP Blocking Peptide; CALCYON; Caly; CALY_HUMAN; D1 dopamine receptor interacting protein; Drd1ip; Neuron specific vesicular protein calcyon; Neuron-specific vesicular protein calcyon; NSG3; RP11-122K13.5; DRD1IP blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for DRD1IP blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for DRD1IP blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 7656955
• NCBI GeneID: 50632
• NCBI Accession #: NP_056537.1
• NCBI GenBank Nucleotide #: NM_015722.3
• UniProt Accession #: Q9NYX4; Q5VWX3; Q5VWY5; Q5VWY6
• Molecular Weight: 17,547 Da
• NCBI Official Full Name: neuron-specific vesicular protein calcyon
• NCBI Official Synonym Full Names: calcyon neuron-specific vesicular protein
• NCBI Official Symbol: CALY
• NCBI Official Synonym Symbols: NSG3; DRD1IP
• NCBI Protein Information: neuron-specific vesicular protein calcyon; calcyon protein; D1 dopamine receptor-interacting protein; dopamine receptor D1 interacting protein; calcyon D1 dopamine receptor-interacting protein (CALCYON)
• UniProt Protein Name: Neuron-specific vesicular protein calcyon
• UniProt Gene Name: CALY
• UniProt Synonym Gene Names: DRD1IP
• UniProt Entry Name: CALY_HUMAN

NCBI Description

The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with D1 dopamine receptor and may interact with other DA receptor subtypes and/or GPCRs. [provided by RefSeq, Jul 2008]

Uniprot Description

calcyon: Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis. Belongs to the NSG family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 10q26.3

Cellular Component: cytoplasmic vesicle membrane; integral to plasma membrane; cytoplasmic vesicle

Molecular Function: protein complex binding; clathrin light chain binding

Biological Process: clathrin cage assembly; dopamine receptor signaling pathway; positive regulation of endocytosis; endocytosis