DMP1 blocking peptide

DMP1 Antibody (N-term) Blocking Peptide

• Gene Names: DMP1; ARHP; ARHR; DMP-1
• Synonyms: DMP1; DMP1 Antibody (N-term) Blocking Peptide; Dentin matrix acidic phosphoprotein 1; DMP-1; Dentin matrix protein 1; DMP1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 513

• Cellular Location: Nucleus. Cytoplasm. Secreted, extracellular space, extracellular matrix. Note: In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus
• Tissue Location: Expressed in tooth particularly in odontoblast, ameloblast and cementoblast
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for DMP1 blocking peptide

May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite.

NCBI and Uniprot Product Information

• NCBI GI #: 7673998
• NCBI GeneID: 1758
• UniProt Accession #: Q13316; O43265; A1L4L3
• Molecular Weight: 54,115 Da
• NCBI Official Full Name: Dentin matrix acidic phosphoprotein 1
• NCBI Official Synonym Full Names: dentin matrix acidic phosphoprotein 1
• NCBI Official Symbol: DMP1
• NCBI Official Synonym Symbols: ARHP; ARHR; DMP-1
• NCBI Protein Information: dentin matrix acidic phosphoprotein 1
• UniProt Protein Name: Dentin matrix acidic phosphoprotein 1
• Protein Family: Dentin matrix acidic phosphoprotein
• UniProt Gene Name: DMP1
• UniProt Synonym Gene Names: DMP-1; Dentin matrix protein 1
• UniProt Entry Name: DMP1_HUMAN

NCBI Description

Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

DMP1: May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite. Defects in DMP1 are the cause of rickets hypophosphatemic autosomal recessive type 1 (ARHR1). A hereditary form of hypophosphatemic rickets, a disorder of proximal renal tubule function that causes phosphate loss, hypophosphatemia and skeletal deformities, including rickets and osteomalacia unresponsive to vitamin D. Symptoms are bone pain, fractures and growth abnormalities. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular region; intracellular membrane-bound organelle; nucleolus; nucleus

Molecular Function: calcium ion binding; integrin binding

Biological Process: extracellular matrix organization and biogenesis

Disease: Hypophosphatemic Rickets, Autosomal Recessive, 1