DLG1 blocking peptide

DLG1 Blocking Peptide (Center)

Gene Names

DLG1; hdlg; DLGH1; SAP97; SAP-97; dJ1061C18.1.1

Synonyms

DLG1; DLG1 Blocking Peptide (Center); Disks large homolog 1; Synapse-associated protein 97; SAP-97; SAP97; hDlg; DLG1 blocking peptide

Ordering

Specificity

The synthetic peptide sequence is selected from aa 663-673 of HUMAN DLG1

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Sequence Length

904

Cellular Location

Membrane; Peripheral membrane protein. Basolateral cell membrane Endoplasmic reticulum membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Cell membrane, sarcolemma Note: Colocalizes with EPB41 at regions of intercellular contacts Basolateral in epithelial cells. May also associate with endoplasmic reticulum membranes. Mainly found in neurons soma, moderately found at postsynaptic densities (By similarity)

Tissue Location

Abundantly expressed in atrial myocardium (at protein level). Expressed in lung fibroblasts, cervical epithelial and B-cells (at protein level). Widely expressed, with isoforms displaying different expression profiles

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for DLG1 blocking peptide

Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel.

NCBI and Uniprot Product Information

NCBI GI #

223590196

NCBI GeneID

1739

UniProt Accession #

Q12959; Q12958; A5YKK7; B4DGU1; B4DGZ8; B7ZMM0; B9EIQ5; D3DXB8; D3DXB9; E7EWL7; E9PG21

Molecular Weight

88,485 Da

NCBI Official Full Name

Disks large homolog 1

NCBI Official Synonym Full Names

discs large MAGUK scaffold protein 1

NCBI Official Symbol

DLG1

NCBI Official Synonym Symbols

hdlg; DLGH1; SAP97; SAP-97; dJ1061C18.1.1

NCBI Protein Information

disks large homolog 1

UniProt Protein Name

Disks large homolog 1

Protein Family

Disks large

UniProt Gene Name

DLG1

UniProt Synonym Gene Names

SAP-97; SAP97

UniProt Entry Name

DLG1_HUMAN

NCBI Description

This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known. [provided by RefSeq, Feb 2011]

Uniprot Description

Essential multidomain scaffolding protein required for normal development (). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel.

Research Articles on DLG1

1. Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia was identified.

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Product Notes

The DLG1 dlg1 (Catalog #AAA9230437) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "DLG1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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DLG1 blocking peptide