DHS blocking peptide

DHS (L87) Peptide

Cat. Num. AAA3004367

• Gene Names: DHPS; DS; DHS; MIG13; NEDSSWI
• Applications: Blocking
• Purity: Synthetic peptide DHS (L87). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: DHS; DHS (L87) Peptide; Deoxyhypusine synthase; DHPS; DS; DHS blocking peptide

• Specificity: This peptide can be used with studies using MBS3004366 DHS (L87) pAb.
• Purity/Purification: Synthetic peptide DHS (L87). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 369

• Applicable Applications for DHS blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for DHS blocking peptide

Deoxyhypusine synthase (DHS) is crucial for the posttranslational formation of hypusine, a modification of a specific lysine residue in eukaryotic initiation factor 5A (eIF-5A). Hypusine is formed by posttranslational modifications involving two enzymatic steps catalyzed by DHS and deoxyhypusine hydroxylase (DOHH). eIF-5A is essential for eukaryotic cell proliferation. DHS, which belongs to the deoxyhypusine synthase family of proteins, is important for the first step in the hypusine biosynthesis pathway. It acts as a catalyst for the NAD-dependent oxidative cleavage of spermidine and the ensuing transfer of the butylamine moiety of spermidine to the eIF-5A protein, to create the intermediate deoxyhypusine residue.

NCBI and Uniprot Product Information

• NCBI GI #: 4503325
• NCBI GeneID: 1725
• NCBI Accession #: NP_001921.1
• NCBI GenBank Nucleotide #: NP_001921.1
• UniProt Accession #: P49366
• NCBI Official Full Name: deoxyhypusine synthase isoform a
• NCBI Official Synonym Full Names: deoxyhypusine synthase
• NCBI Official Symbol: DHPS
• NCBI Official Synonym Symbols: DS; DHS; MIG13; NEDSSWI
• NCBI Protein Information: deoxyhypusine synthase
• UniProt Protein Name: Deoxyhypusine synthase
• Protein Family: Deoxyhypusine synthase
• UniProt Gene Name: DHPS
• UniProt Synonym Gene Names: DS; DHS
• UniProt Entry Name: DHYS_HUMAN

NCBI Description

This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2011]

Uniprot Description

DHPS: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. Belongs to the deoxyhypusine synthase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; EC 2.5.1.46; Transferase

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: cytosol

Molecular Function: protein binding; deoxyhypusine synthase activity

Biological Process: cellular protein metabolic process; translation; positive regulation of cell proliferation; positive regulation of T cell proliferation; hypusine biosynthetic process from peptidyl-lysine; post-translational protein modification; glucose homeostasis; spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase; protein homotetramerization