DGKD blocking peptide

DGKD Antibody (C-term) Blocking Peptide

• Gene Names: DGKD; dgkd-2; DGKdelta
• Synonyms: DGKD; DGKD Antibody (C-term) Blocking Peptide; Diacylglycerol kinase delta; DAG kinase delta; 130 kDa diacylglycerol kinase; Diglyceride kinase delta; DGK-delta; KIAA0145; DGKD blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human DGKD. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 1214

• Cellular Location: Isoform 2: Cytoplasm.
• Tissue Location: Isoform 2 is ubiquitously expressed also in tumor tissues. Isoform 1 is expressed in ovary, spleen and some tumor-derived cells.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for DGKD blocking peptide

May function as signaling molecule.

NCBI and Uniprot Product Information

• NCBI GI #: 116241328
• NCBI GeneID: 8527
• UniProt Accession #: Q16760; Q14158; Q6PK55; Q8NG53
• Molecular Weight: 130,326 Da
• NCBI Official Full Name: Diacylglycerol kinase delta
• NCBI Official Synonym Full Names: diacylglycerol kinase delta
• NCBI Official Symbol: DGKD
• NCBI Official Synonym Symbols: dgkd-2; DGKdelta
• NCBI Protein Information: diacylglycerol kinase delta
• UniProt Protein Name: Diacylglycerol kinase delta
• Protein Family: Diacylglycerol kinase
• UniProt Gene Name: DGKD
• UniProt Synonym Gene Names: KIAA0145; DAG kinase delta; DGK-delta
• UniProt Entry Name: DGKD_HUMAN

NCBI Description

This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

DGKD: May function as signaling molecule. Belongs to the eukaryotic diacylglycerol kinase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - glycerophospholipid; Lipid Metabolism - glycerolipid; Motility/polarity/chemotaxis; Kinase, lipid; EC 2.7.1.107

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: cytoplasm; plasma membrane

Molecular Function: diacylglycerol kinase activity; protein binding; protein heterodimerization activity; protein homodimerization activity

Biological Process: diacylglycerol metabolic process; platelet activation; protein homooligomerization; response to organic substance; signal transduction