DDX20 blocking peptide

DDX20 Antibody (C-term) Blocking Peptide

• Gene Names: DDX20; DP103; GEMIN3
• Synonyms: DDX20; DDX20 Antibody (C-term) Blocking Peptide; Probable ATP-dependent RNA helicase DDX20; Component of gems 3; DEAD box protein 20; DEAD box protein DP 103; Gemin-3; DP103; GEMIN3; DDX20 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 824

• Cellular Location: Cytoplasm. Nucleus, gem. Note: Localized in subnuclear structures next to coiled bodies, called Gemini of Cajal bodies (Gems)
• Tissue Location: Ubiquitous.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for DDX20 blocking peptide

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).

NCBI and Uniprot Product Information

• NCBI GI #: 12643886
• NCBI GeneID: 11218
• UniProt Accession #: Q9UHI6; Q96F72; Q9NVM3; Q9UF59; Q9UIY0; Q9Y659; B4DWV7
• Molecular Weight: 14,272 Da
• NCBI Official Full Name: Probable ATP-dependent RNA helicase DDX20
• NCBI Official Synonym Full Names: DEAD-box helicase 20
• NCBI Official Symbol: DDX20
• NCBI Official Synonym Symbols: DP103; GEMIN3
• NCBI Protein Information: probable ATP-dependent RNA helicase DDX20
• UniProt Protein Name: Probable ATP-dependent RNA helicase DDX20
• Protein Family: Probable ATP-dependent RNA helicase
• UniProt Gene Name: DDX20
• UniProt Synonym Gene Names: DP103; GEMIN3
• UniProt Entry Name: DDX20_HUMAN

NCBI Description

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs. [provided by RefSeq, Jul 2008]

Uniprot Description

GEMIN3: an ubiquitous DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. Interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly.

Protein type: Helicase; EC 3.6.4.13; RNA splicing; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 1p21.1-p13.2

Cellular Component: cytoplasm; cytoskeleton; cytosol; membrane; nucleoplasm; nucleus; SMN complex

Molecular Function: ATP-dependent RNA helicase activity; protein binding

Biological Process: assembly of spliceosomal tri-snRNP; negative regulation of transcription from RNA polymerase II promoter; nuclear import; positive regulation of apoptosis; RNA processing; RNA secondary structure unwinding; spliceosomal snRNP biogenesis