DCPS blocking peptide
DCPS Antibody (Center) Blocking Peptide
Gene Names
DCPS; ARS; DCS1; HSL1; HINT5; HINT-5; HSPC015
Synonyms
DCPS; DCPS Antibody (Center) Blocking Peptide; m7GpppX diphosphatase; DCS-1; Decapping scavenger enzyme; Hint-related 7meGMP-directed hydrolase; Histidine triad nucleotide-binding protein 5; Histidine triad protein member 5; HINT-5; Scavenger mRNA-decapping enzyme DcpS; DCS1; HINT5; DCPS blocking peptide
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
337
Cellular Location
Cytoplasm. Nucleus. Note: Predominantly localized in the nucleus. Nucleocytoplasmic shuttling protein that can transiently enter the cytoplasm in mammalian cells in a XPO1/CRM1-dependent manner
Tissue Location
Detected in liver, brain, kidney, testis and prostate.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for DCPS blocking peptide
Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre- mRNAs. Inhibits activation-induced cell death.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
38,609 Da
NCBI Official Full Name
m7GpppX diphosphatase
NCBI Official Synonym Full Names
decapping enzyme, scavenger
NCBI Official Symbol
DCPS
NCBI Official Synonym Symbols
ARS; DCS1; HSL1; HINT5; HINT-5; HSPC015
NCBI Protein Information
m7GpppX diphosphatase
UniProt Protein Name
m7GpppX diphosphatase
Protein Family
UniProt Gene Name
DCPS
UniProt Synonym Gene Names
DCS1; HINT5; HINT-5
UniProt Entry Name
DCPS_HUMAN
Uniprot Description
DCPS: Necessary for the complete degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA fragments shorter than 10 nucleotides that are produced by 3'->5' exosome-mediated mRNA decay. Releases m7GMP. Can also degrade m7GDP to m7GMP. Has no activity towards mRNA molecules longer than 25 nucleotides. Belongs to the HIT family.
Protein type: RNA splicing; Hydrolase; EC 3.6.1.59
Chromosomal Location of Human Ortholog: 11q24.2
Cellular Component: cytoplasm; cytosol; mitochondrion; nucleoplasm; nucleus
Molecular Function: exoribonuclease activity; m7G(5')pppN diphosphatase activity; protein binding; RNA 7-methylguanosine cap binding
Biological Process: mRNA catabolic process, deadenylation-dependent decay; negative regulation of programmed cell death; nuclear mRNA cis splicing, via U2-type spliceosome
Disease: Al-raqad Syndrome
Research Articles on DCPS
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Product Notes
The DCPS dcps (Catalog #AAA9222270) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "DCPS, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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