DCLK2 blocking peptide

DCLK2 Peptide

Cat. Num. AAA152714

• Gene Names: DCLK2; CL2; DCK2; CLIK2; DCDC3; CLICK2; DCDC3B; DCAMKL2; CLICK-II
• Applications: Blocking (BL)
• Synonyms: DCLK2; DCLK2 Peptide; CL2; DCK2; CLIK2; DCDC3; CLICK2; DCDC3B; DCAMKL2; CLICK-II; CaMK-like CREB regulatory kinase 2; doublecortin-like kinase 2; DCLK2 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 766

• Applicable Applications for DCLK2 blocking peptide: Blocking (BL)
• Application Notes: DCLK2 peptide is used for blocking the activity of DCLK2 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 14 amino acids near the carboxy terminus of human DCLK2.
• Preparation and Storage: Store DCLK2 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 156713428
• NCBI GeneID: 166614
• NCBI Accession #: NP_001035350
• NCBI GenBank Nucleotide #: NM_001040260.3
• UniProt Accession #: Q8N568; Q59GC8; Q8N399; C9J5Q9
• Molecular Weight: 85,384 Da
• NCBI Official Full Name: serine/threonine-protein kinase DCLK2 isoform a
• NCBI Official Synonym Full Names: doublecortin-like kinase 2
• NCBI Official Symbol: DCLK2
• NCBI Official Synonym Symbols: CL2; DCK2; CLIK2; DCDC3; CLICK2; DCDC3B; DCAMKL2; CLICK-II
• NCBI Protein Information: serine/threonine-protein kinase DCLK2; CaMK-like CREB regulatory kinase 2; doublecortin and CaM kinase-like 2; doublecortin-like and CAM kinase-like 2; doublecortin domain-containing protein 3B
• UniProt Protein Name: Serine/threonine-protein kinase DCLK2
• Protein Family: Serine/threonine-protein kinase
• UniProt Gene Name: DCLK2
• UniProt Synonym Gene Names: DCAMKL2; DCDC3B; DCK2; CL2; CLICK-II; CLICK2
• UniProt Entry Name: DCLK2_HUMAN

NCBI Description

This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010]

Uniprot Description

DCAMKL2: Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; CAMK group; DCAMKL family

Chromosomal Location of Human Ortholog: 4q31.3

Cellular Component: cytoskeleton; cytoplasm

Molecular Function: protein serine/threonine kinase activity; ATP binding

Biological Process: protein amino acid phosphorylation